Mice with targeted tyrosine kinase, lyn, disruption

Details Mice with targeted tyrosine kinase, lyn, disruption Mice with targeted tyrosine kinase, lyn, disruption

1996-10-18

1999-01-12

Chambers, Jasemine C.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

4351723, 800DIG1, 800DIG3, 800DIG4, 424 91, 424 92, C12N 1500

Patent

active

058593144

ABSTRACT:
A non-human animal carrying a disruption of a gene encoding a lyn protein tyrosine kinase provides a convenient system for the study of diseases associated with or caused by lyn deficiency, and for the testing of therapeutic agents for the treatment or prevention of diseases which include autoimmune diseases, allergy, asthma and malignant disease.

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patent: 5545808 (1996-08-01), Hew et al.
Salter, et al. Transgenic Chickens: Insertion of Retroviral Genes into the Chicken Germ Line. Virology, vol. 157, pp. 236-240, 1987.
Houdebine, L. M. Production of pharmaceutical proteins from transgenic animals. J. of Biotech. vol. 34, pp. 269-287, 1994.
NIH panel. Report and recommendations of the panel to assess the NIH investment in research on gene therapy, Dec. 7, 1995.
Bradley et al. Modifying the mouse: design and desire. Biotechnology, vol. 10, pp. 534-539, May 1992.
Fassler et al. Knockout Mice: How to make them and why. The immunological approach. Int. Arch. Allergy Immunol., vol. 106, pp. 323-334, 1995.

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