Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – The nonhuman animal is a model for human disease
Patent
1997-10-15
2000-08-22
Crouch, Deborah
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
The nonhuman animal is a model for human disease
424 921, 435455, 514 44, C12N 500, C12N 1500, A61K 4900, G01N 3100
Patent
active
06107540&
ABSTRACT:
The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof.
REFERENCES:
Liu, A. Y., et al., "Prostatic Cell Lineage Markers: Emergence of BCL2.sup.+ Cells of Human Prostate Cancer Xenograft LuCaP 23 Following Castration," Int. J. Cancer, 65:85-89 (1996).
Lubaroff, D. M., et al., "Survival of Human Prostate Carcinoma, Benign Hyperplastic Prostate Tissues, and IL-2-Activated Lymphocytes in SCID Mice," The Prostate, 27:32-41 (1995).
Wainstein, M. A., et al., "CWR22: Androgen-Dependent Xenograft Model Derived from a Primary Human Prostatic Carcinoma," Cancer Research, 54:6049-6052 (1994).
Pretlow, T. G., et al., "Xenografts of Primary Human Prostatic Carcinoma," Journal of the National Cancer Institute, 85(5):394-398 (1993).
Pretlow, T. G. et al., "Transplantation of Human Prostatic Carcinoma into Nude Mice in Matrigel," Cancer Research, 51:3814-3817 (1991).
Perez-Stable et al., Cancer Research, vol. 57, pp. 900-906. (Mar. 1, 1997).
Sato et al., Journal of Urology, vol. 155; 5, p. 338A. (May 4, 1996).
van Weerden et al., American Journal of Pathology, vol. 149: 3, pp. 1055-1062. (Sep. 1996).
Klein Karen A.
Reiter Robert E.
Sawyer Charles L.
Witte Owen N.
Crouch Deborah
Martin Jill D.
The Regents of the University of California
LandOfFree
Mice models of human prostate cancer progression does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Mice models of human prostate cancer progression, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mice models of human prostate cancer progression will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-583145