Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – Transgenic nonhuman animal
Patent
1997-04-15
2000-06-27
Campell, Bruce R.
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
Transgenic nonhuman animal
800 3, 800 9, 800 21, 800 22, 800 25, 435455, 435463, 4353201, 435325, C12N 1509, C12N 1563, C12N 1500, C12N 500
Patent
active
060809116
ABSTRACT:
The present invention provides mouse models of growth hormone insensitivity including Laron syndrome. In particular, the present invention provides transgenic mice incapable of expressing functional growth hormone receptor including mice which further cannot express functional growth hormone binding protein. The invention further provides methods for testing the usefulness of chemical compounds in the treatment of growth hormone insensitivity and diabetic end-organ disease.
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Fleay in 1
Kopchick John J.
Zhou Yihua
Campell Bruce R.
Martin Jill D.
Ohio University
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