Mice lacking inward-rectifying potassium channel Kir6.1

Details Mice lacking inward-rectifying potassium channel Kir6.1 Mice lacking inward-rectifying potassium channel Kir6.1

2006-10-03

2006-10-03

Nguyen, Dave Trong (Department: 1632)

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

Transgenic nonhuman animal

Reexamination Certificate

active

07115797

ABSTRACT:
Mice homozygous for the lack of inward-rectifying potassium channel Kir6.1 gene are disclosed. The mice causes a high incidence of sudden death associated with arrhythmia (atrioventricular block) caused by spontaneous cardiac ischemia, a condition similar to Prinzmetal angina (variant angina) in human, representing an animal model of Prinzmetal angina. Mice heterozygous for the lack of inward-rectifying potassium channel Kir6.1 gene are also disclosed, which are used as parent mice for reproduction of the homozygous mice.

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