Mice lacking expression of CTLA-4 receptor

Details Mice lacking expression of CTLA-4 receptor Mice lacking expression of CTLA-4 receptor

1995-11-06

1998-02-03

Chambers, PHD., Jasemine C.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

4351723, 435 691, 435 912, 435325, 435 693, 4353201, 536 231, 536 235, 536 2353, 536 2431, 935 23, 935 78, 935 79, 935 81, 935 70, 935 71, C12N 500, C12N 1500

Patent

active

057146675

ABSTRACT:
Disclosed is a mouse in which expression of the gene encoding the CTLA-4 receptor is suppressed. Also disclosed is a nucleic acid construct useful in preparing such a mouse, and a cell line containing such construct.

REFERENCES:
Capecchi, Scientific American, vol. 270, pp. 34-41, Mar. 1994.
Shahinian et al., Science, vol. 261, p. 609, 1993.
Brunet et al., Nature, vol. 328, p. 267, 1987.
Tivol, et al., Immunity, 3, 541-547, Nov., 1995.
Immen, Wallace, The Globe and Mail, Nov. 10, 1995.

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