Multicellular living organisms and unmodified parts thereof and – Method of using a transgenic nonhuman animal in an in vivo...
Reexamination Certificate
2006-01-10
2006-01-10
Woitach, Joseph (Department: 1635)
Multicellular living organisms and unmodified parts thereof and
Method of using a transgenic nonhuman animal in an in vivo...
C800S008000, C800S009000, C800S013000, C800S018000, C800S021000, C800S025000
Reexamination Certificate
active
06984771
ABSTRACT:
The present invention describes a recombinant rodent model for depression. More particularly, the rodent comprises cells expressing mutations in the WFS1 gene. The rodent is preferably a mouse heterologous for mutations in exon 8 of the WFS1 gene. Preferably, the mutations yield a non-functional wolframin protein that lacks all or some of it transmembrane regions. Methods and compositions for making and using the mouse and cells thereof are disclosed.
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Huff Rita M.
Roberds Steven L.
Pharmacia & Upjohn Company
Pharmacia & Upjohn Company
Whiteman Brian
Woitach Joseph
Wootton Thomas A.
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