Mice deficient in nerve growth factor receptors encoded by trkB

Details Mice deficient in nerve growth factor receptors encoded by trkB Mice deficient in nerve growth factor receptors encoded by trkB

1993-10-14

1997-04-29

Crouch, Deborah

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

435325, 435354, 935 60, C12N 500, C12N 1500

Patent

active

056251211

ABSTRACT:
The present invention provides mice and mouse cell lines having a homozygous or heterozygous deficiency in a gene encoding a neurotrophin receptor. In a preferred embodiment of this invention, mice and cell lines carry a trkB locus specifically targeted within its tyrosine protein kinase sequences. Mice homozygous for this mutation express gp95.sup.trkB receptor of unknown function but not the high affinity functional gp145.sup.trkB tyrosine protein kinase receptors. This mutation results in multiple CNS and PNS neuronal deficiencies and in a postembryonic lethal phenotype. Such genetically modified mice are useful in model systems for studying human diseases involving neuronal degeneration and neuronal cell loss, as well as in screening for genes, proteins, or other compounds that may prevent or impede neuronal cell death or stimulate neuronal regeneration.

REFERENCES:
Lee et al (1992) Cell 69, 737-749.
Klein et al (1990) Cell 61, 647-656.
Cell, vol. 69, May 29, 1992, pp. 737-749, K.F. Lee et al., "Targeted Mutation of the Gene Encoding the Low Affinity NGF Receptor p75 Leads to Deficits in the Peripheral Sensory Nervous System".
J. Cell. Biochem., Supplement 17, part A, Jan. 9-31, 1993, p. 234, abstr. R. Klein et al. "Germline Targeting of the Mouse trkB Gene".
Nature, vol. 336, Nov. 24, 1988, pp. 348-352, S.L. Mansour et al. "Disruption of the Proto-oncogene int-2 in Mouse Embryo-derived Stem Cells: A General Strategy For Targeting Mutations to Non-selectable Genes".
Cell, vol. 75, No. 1, Oct. 8, 1993, pp. 113-122, R. Klein et al. "Targeted Disruption of the trkB Neurotrophin Receptor Gene Results in Nervous System Lesions and Neonatal Death".
Trends in Genetics, 5 (3), pp. 70-76, 1989.
T.M. DeChiara et al., Nature, 345, pp. 78-80, 1990.
S.L. Knight et al., Nucleic Acids Research, 8, 24, pp. 5949-5964, 1990.
P.L. Schwartzberg et al., Science, 246, pp. 799-803, 1989.
O. Smithies, et al., Nature, 317, pp. 230-234, 1985.

Affiliated with

Also associated with

Rating

Mice deficient in nerve growth factor receptors encoded by trkB does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Mice deficient in nerve growth factor receptors encoded by trkB, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mice deficient in nerve growth factor receptors encoded by trkB will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-707475