Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...
Patent
1990-12-28
1994-02-08
Nucker, Christine M.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Chemical modification or the reaction product thereof, e.g.,...
530395, 530806, 530807, 530868, 424 88, C07K 110, C07K 114, C07K 104
Patent
active
052849350
ABSTRACT:
The invention is directed to methods and materials useful in treating autoimmune diseases. The therapeutic agents are of the formula X--MHC--peptide or MHc--peptide--X wherein X represents a functional moiety selected from a toxin and a labeling group; MHC is an effective portion of the MHC glycoprotein, said glycoprotein dissociated from the cell surface on which it normally resides; and "peptide" represents an antigenic peptide sequence associated with an autoantigen;--represents a covalent bond or a linker bound to X and MHC or to X and peptide by covalent bonds; and--represents a covalent bond, a noncovalent association, or a linker covalently bound to or associated with the MHC and peptide. These complexes can be used to target helper T-cells which are specifically immunoreactive with autoantigens.
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Clark Brian R.
Lerch L. Bernard
Sharma Somesh D.
Anergen Inc.
Cunningham T.
Nucker Christine M.
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