MHC-mediated toxic conjugates useful in ameliorating autoimmunit

Details MHC-mediated toxic conjugates useful in ameliorating autoimmunit MHC-mediated toxic conjugates useful in ameliorating autoimmunit

1989-06-21

1993-03-16

Nucker, Christine

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530402, 530403, 530395, 514903, 424 88, A61K 3702, A61K 3528

Patent

active

051944251

ABSTRACT:
The invention is directed to methods and materials useful in treating autoimmune diseases. The therapeutic agents are of the formula X.sup.1 MHC.sup.2 peptide or MHC.sup.2 peptide.sup.1 X wherein X represents a functional moiety selected from a toxin and a labeling group; MHC is an effective portion of the MHC glycoprotein, said glycoprotein dissociated from the cell surface on which it normally resides; and "peptide" represents an antigenic peptide sequence associated with an autoantigen; .sup.1 represents a covalent bond or a linker bound to X and MHC or to X and peptide by covalent bonds; and .sup.2 represents a covalent bond, a noncovalent association, or a linker covalently bound to or associated with the MHC and peptide. These complexes can be used to target helper T-cells which are specifically immunoreactive with autoantigens.

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