MHC conjugates useful in ameliorating autoimmunity

Details MHC conjugates useful in ameliorating autoimmunity MHC conjugates useful in ameliorating autoimmunity

1991-04-23

1993-11-09

Nucker, Christine M.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Chemical modification or the reaction product thereof, e.g.,...

530402, 530868, 424 88, C07K 1700, C07K 1702, A61K 39385

Patent

active

052604225

ABSTRACT:
The present invention is directed to complexes consisting essentially of an isolated MHC component and an autoantigenic peptide associated with the antigen binding site of the MHC component. These complexes are useful in treating autoimmune disease.

REFERENCES:
patent: 4199565 (1980-04-01), Fullerton
patent: 4400376 (1983-08-01), Sanderson
patent: 4478823 (1984-10-01), Sanderson
patent: 4675382 (1987-06-01), Murphy
patent: 4681760 (1987-07-01), Fathman
patent: 4714759 (1987-12-01), Whitaker
patent: 4762915 (1988-08-01), Kung et al.
patent: 5130297 (1992-07-01), Sherma et al.
Babbitt, B. P. et al. (1985) Nature 317:359-361.
Bjorkman, P. J. et al. (1987) Nature 329:506-512.
Bjorkman, P. J. et al. (1987) Nature 329:512-518.
Buus, S. et al. (1987) Science 235:1353-1358.
Diener, E. et al. (1986) Science 231:148-150.
Killen, J. A. et al. (1984) J. Immunol. 133:2549-2553.
Livingstone, A. M. et al. (1987) Ann. Rev. Immunol. 5:477-501.
Marx, J. L. (1987) Science 238:613-614.
Paul, W. E. (1989) Fundamental Immunol. Raven Press, New York, pp. 69-73.
Rennie, D. P. et al. (1983) The Lancet (Dec. 10) 1338-1340.
Sterz, R. K. M. et al. (1985) J. Immunol. 134:841-846.
Townsend, A. et al. (1987) Nature 329:482-483.
Unanue, E. R. et al. (1987) Science 236:551-557.
Watts, T. H. et al. (1984) Proc. Natl. Acad. Sci. USA 81:7564-7568.
Watts, T. H. et al. (1985) Proc. Natl. Acad. Sci. USA 82:5480-5484.
Watts, T. H. et al. (1987) Ann. Rev. Immunol. 5:461-475.
Clemetson, K. J. et al. (1986) In Membrane proteins: A Laboratory Manual, Ed. Azzi, A. et al., pp. 57-64.
Cooperman (1979) In Ribosomes Structure, Function, and Genetics. Ed. Chambliss et al. University Park Press, Baltimore, Md. pp. 531-554.
Estess, P. et al. (1986) In Regulation of immune gene expression, Ed. Feldman, M. et al., Humana Press, pp. 3-19.
Hall et al. (1985) Biochemistry 24:5702-5711.
Harcourt, G. et al. (1987) Immunol. Today 8(11):(news and features section).
Hixson, J. R. Medical Tribune (Jan. 24, 1985) pp. 4-5.
Liu, M. A. et al. (1988) Science 239:395-398.
Marrack, P. et al. (1988) Nature 332:840-842.
Nakanishi, M. et al. (1983) Molec. Immunol. 20:1227-1231.
Pastan, I. et al. (1986) Cell 47:641-648.
Sekaly, R. P. et al. (1986) J. Exp. Med. 164:1490-1504.
Shizuru, J. A. et al. (1988) Science 240:659-662.
Springer, T. A. et al. (1976) Proc. Natl. Acad. Sci. USA 73:2481-2485.
Sriram, S. et al. (1987) Concepts Immunopathol. 4:275-286.
Vitetta, E. S. et al. (1987) Science 238:1098-1104.
Watts, T. H. et al. (1988) In Processing and presentation of antigens, Academic Press, pp. 143-154.
Binz, H. et al. (1979) J. Exp. Med. 150:1084-1097.
Gasciogne, N. R. J. et al. (1987) Proc. Natl. Acad. Sci. USA. 84:2396-2340.
Margulies, D. H. et al. (1987) Immunol. Res. 6:101-116.
McCluskey, J. et al. (1988) J. Immunol. 141:1451-1455.
Lamb et al. (1987) i EMBO J. 6:1245-1249.
Berkower et al. (1986) J. Immunol. 136:2498-2502.
Townsend et al. (1986) Cell 44:959-968.
Sanderson et al. (1973) Transplantation 16:304-312.
Turner et al. (1976) J. Biol. Chem. 250:4512-4519.
Gorga et al. (1987) J. Biol. Chem. 262:16087-16094.
Zamvil et al. (1985) J. Exp. Med. 162:2107-2124.
Zamvil et al. (1985) Nature 317:355-358.
Ceredig, R. et al. (1986) Eur. J. Immunol. 16:30-34.
Essery, G. et al. (1988) Immunology 64:413-417.
Jenkins, M. K. et al. (1987) J. Exp. Med. 165:302-319.
Klein, J. (1984) Immunol. Reviews 81:177-202.
Lamb, J. R. (1983) J. Exp. Med. 157:1434-1447.
Lamb, J. R. (1984) Nature 308:72-74.
Lamb, J. R. et al. (1986) Immunology 57:331-335.
Lamb, J. R. et al. (1987) Eur. J. Immunol. 17:1641-1644.
Larche, M. et al. (1988) Immunology 64:101-105.
Madsen, J. C. et al. (1988) Nature 332:161-164.
Miller, S. D. et al. (1979) J. Exp. Med. 149:758-773.
Nau, G. J. et al. (1987) J. Immunol. 139:114-122.
Quill, H. et al. (1987) J. Immunol. 138:3704-3712.
Suzuki, G. et al. (1988) J. Immunol. 140:1359-1365.
Zanders, E. D. et al. (1983) Nature 303:625-627.
Zanders, E. D. et al. (1985) Eur. J. Immunol. 15:302-305.
Germain, R. N. (1981) J. Immunol. 127:1964-1966.
Lamb, J. R. et al. (1987) EMBO J. 6:1245-1249.
Paul, W. F. (ed) Fund. Immunol. 1989 pp. 506-507, Raven Press, N.Y.
Doyle, C. et al. Nature 330:256-259. Nov. 1987 Interaction between CP4 and Class II MHC . . . .
Golding, H. et al. Nature 317:425-427, Oct. 1985, T-cell recognition of a chimaeric class II . . . .
Buss, S. et al. Science 242:1045-1047 (1988) "Analogues peptides constitutively occupy the antigan bing site on Ig".
Gvillet, J. et al. Science 235:865-870 (1987), "Immunological self, non-self discrimination".
Puri, et al. Eur. J. Immunol. 10:273-281 (1980). "Mechanism of antigen binding by T cells H-2 (I-A)-restricted binding of antigen plus, Ia by helper cells."
Turkewicz, A. P. et al. Mol-Immunol. 20(11):1139-1147, (1983), "Large scale purification of murine IRK and I-E.sup.k antigens and characterization of the purified proteins."

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