MHC conjugates useful in ameliorating autoimmunity

Details MHC conjugates useful in ameliorating autoimmunity MHC conjugates useful in ameliorating autoimmunity

1995-06-05

2000-08-22

Chan, Christina Y.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

4241851, 530300, 530350, 530395, 530403, 530868, A61K 3900, A61K 39385, C07K 14435, C07K 14705

Patent

active

061068403

ABSTRACT:
The present invention is directed to complexes consisting essentially of an isolated MHC component and an autoantigenic peptide associated with the antigen binding site of the MHC component. These complexes are useful in treating autoimmune disease.

REFERENCES:
patent: 4675382 (1987-06-01), Murphy, Jr.
patent: 4714759 (1987-12-01), Whitaker
patent: 5130297 (1992-07-01), Sharma et al.
patent: 5260422 (1993-11-01), Clark et al.
patent: 5284935 (1994-02-01), Clark et al.
patent: 5468481 (1995-11-01), Sharma et al.
patent: 5820866 (1998-10-01), Kappler et al.
Babbitt, B.P. et al. (1985) Nature 317: 359-361.
Bjorkman, P.J. et al. (1987) Nature 329: 506-512, 512-518.
Buus, S. et al. (1987) Science 235: 1353-1358.
Diener, E. et al. (1986) Science 231: 148-150.
Killen, J.A. et al. (1984) J. Immunol. 133: 2549-2553.
Livingstone, A.M. et al. (1987) Ann. Rev. Immunol. 5: 477-501.
Marx, J.L. (1987) Science 238: 613-614.
Paul, W.E. (1989) Fundamental Immunol. Raven Press, New York, pp. 69-73.
Puri, J. et al. (1980) Eur. J. Immunol. 10: 273-281.
Rennie, D.P. et al. (1983) The Lancet (Dec. 10) 1338-1340.
Sterz, R.K.M. et al. (1985) J. Immunol. 134: 841-846.
Townsend, A. et al. (1987) Nature 329: 482-483.
Turkewitz, A.P. et al. (1983) Molec. Immunol. 20: 1139-1147.
Unanue, E.R. et al. (1987) Science 236: 551-557.
Watts, T.H. et al. (1984) Proc. Natl. Acad. Sci. USA 81: 7564-7568.
Watts, T.H. et al. (1985) Proc. Natl. Acad. Sci. USA 82: 5480-5484.
Watts, T.H. et al. (1987) Ann. Rev. Immunol. 5: 461-475.
Clemetson, K.J. et al. (1986) In Membrane proteins: A Laboratory Manual, Ed. Azzi, A. et al., pp. 57-64.
Cooperman (1979) In Ribosomes Structure, Function, and Genetics. Ed. Chambliss et al. University Park Press, Baltimore MD. pp. 531-554.
Estess, P. et al. (1986) In Regulation of immune gene expression, Ed. Feldman, M. et al., Humana Press, pp. 3-19.
Guillet et al. (1987) Science 235: 865-870.
Hall et al. (1985) Biochemistry 24: 5702-5711.
Harcourt, G. et al. (1987) Immunol. Today 8 (11): (news and features section).
Hixson, J.R. Medical Tribune (Jan. 24, 1985) pp. 4-5.
Liu, M.A. et al. (1988) Science 239: 395-398.
Marrack, P. et al. (1988) Nature 332: 840-842.
Nakanishi, M. et al. (1983) Molec. Immunol. 20: 1227-1231.
Pastan, I. et al. (1986) Cell 47: 641-648.
Sekaly, R.P. et al. (1986) J. Exp. Med. 164: 1490-1504.
Shizuru, J.A. et al. (1988) Science 240: 659-662.
Springer, T.A. et al. (1976) Proc. Natl. Acad. Sci. USA 73: 2481-2485.
Sriram, S. et al. (1987) Concepts Immunopathol. 4: 275-286.
Vitetta, E.S. et al. (1987) Science 238: 1098-1104.
Watts, T.H. et al. (1988) In Processing and presentation of antigens, Academic Press, pp. 143-154.
Binz, H. et al. (1979) J. Exp. Med. 150: 1084-1097.
Gasciogne, N.R.J. et al. (1987) Proc. Natl. Acad. Sci. USA. 84: 2396-2340.
Margulies, D.H. et al. (1987) Immunol. Res. 6: 101-116.
McCluskey, J. et al. (1988) J. Immunol. 141: 1451-1455.
Lamb et al. (1987) EMBO J. 6: 1245-1249.
Berkower et al. (1986) J. Immunol. 136: 2498-2502.
Townsend et al. (1986) Cell 44: 959-968.
Sanderson et al. (1973) Transplantation 16: 304-312.
Turner et al. (1976) J. Biol. Chem. 250: 4512-4519.
Gorga et al. (1987) J. Biol. Chem. 262: 16087-16094.
Zamvil et al. (1985) J. Exp. Med. 162: 2107-2124.
Zamvil et al. (1985) Nature 317: 355-358.
Ceredig, R. et al. (1986) Eur. J. Immunol. 16: 30-34.
Essery, G. et al. (1988) Immunology 64: 413-417.
Jenkins, M.K. et al. (1987) J. Exp. Med. 165: 302-319.
Klein, J. (1984) Immunol. Reviews 81: 177-202.
Lamb, J.R. (1983) J. Exp. Med. 157: 1434-1447.
Lamb, J.R. (1984) Nature 308: 72-74.
Lamb, J.R. et al. (1986) Immunology 57: 331-335.
Lamb, J.R. et al. (1987) Eur. J. Immunol. 17: 1641-1644.
Larche, M. et al. (1988) Immunology 64: 101-105.
Madsen, J.C. et al. (1988) Nature 332: 161-164.
Miller, S.D. et al. (1979) J. Exp. Med. 149: 758-773.
Nau, G.J. et al. (1987) J. Immunol. 139: 114-122.
Quill, H. et al. (1987) J. Immunol. 138: 3704-3712.
Suzuki, G. et al. (1988) J. Immunol. 140: 1359-1365.
Zanders, E.D. et al. (1983) Nature 303: 625-627.
Zanders, E.D. et al. (1985) Eur. J. Immunol. 15: 302-305.
Germain, R.N. (1981) J. Immunol. 127:1964-1966.
Buss, S. et al. (1988) Science 242:1045-1047.
Sharma, S.D. et al. (1991) Proc. Natl. Acad. Sci. USA 88:11465-11469.
Nag, B. et al. (1992) J. of Immunol. 148(2):369-372.

Affiliated with

Also associated with

Rating

MHC conjugates useful in ameliorating autoimmunity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with MHC conjugates useful in ameliorating autoimmunity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and MHC conjugates useful in ameliorating autoimmunity will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-577604