Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...
Reexamination Certificate
2006-11-28
2006-11-28
Chan, Christina (Department: 1644)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Chemical modification or the reaction product thereof, e.g.,...
C530S350000, C530S391700, C530S402000
Reexamination Certificate
active
07141656
ABSTRACT:
The present invention relates to novel complexes of major histocompability complex (MHC) molecules and uses of such complexes. In one aspect, the invention relates to loaded MHC complexes that include at least one MHC molecule with a peptide-binding groove and a presenting peptide non-covalently linked to the MHC protein. In another aspect, the invention features single chain MHC class II peptide fusion complexes with a presenting peptide covalently linked to the peptide binding grove of the complex. MHC complexes of the invention are useful for a variety of applications including: 1) in vitro screens for identification and isolation of peptides that modulate activity of selected T cells, including peptides that are T cell receptor antagonists and partial agonists, and 2) methods for suppressing or inducing an immune response in a mammal.
REFERENCES:
patent: 5130297 (1992-07-01), Sharma et al.
patent: 5194425 (1993-03-01), Sharma et al.
patent: 5260422 (1993-11-01), Clark et al.
patent: 5284935 (1994-02-01), Clark et al.
patent: 5583031 (1996-12-01), Stern
patent: 5827737 (1998-10-01), Peterson et al.
patent: 5869270 (1999-02-01), Rhode et al.
patent: 6232445 (2001-05-01), Rhode et al.
patent: WO 89/12458 (1989-12-01), None
patent: WO 92/18150 (1992-10-01), None
patent: WO 93/10220 (1993-03-01), None
patent: WO 93/09810 (1993-05-01), None
patent: WO 93/16191 (1993-08-01), None
patent: WO 93/17095 (1993-09-01), None
patent: WO 94/18998 (1994-09-01), None
patent: WO 94/25054 (1994-11-01), None
patent: WO 95/23814 (1995-09-01), None
patent: WO 95/23814 (1995-09-01), None
patent: WO 96/04314 (1996-02-01), None
patent: WO 96/05228 (1996-02-01), None
patent: WO 96/40944 (1996-12-01), None
patent: WO 97/28191 (1997-08-01), None
Janeway et al Immunobiology, Fourth Edition, 1999, Garland Press NY London, pp. 119 and 136-137.
Germain, RN. in Fundamental Immunology, Fourth Edition, ed. by WE Paul. Lippincott-Raven, Philadelphia. [1999] pp. 287-340.
Kozono, et al.;Nature; Production of Soluble MHC Class II Proteins with Covalently Bound Single Peptides; 369:151-154; May 12, 1994.
Godeau,. et al.;Journal of Biological Chemistry; Purification and Ligand Binding of a Soluble Class I Major Histocompatibility Complex Module Consisting of the First Three Domains of H-2KdFused to β2-Microglobulin Expressed in the Baculovirus-Insect Cell System; 267:24223-242295; Dec. 5, 1992.
H. Konozo, et al.,Nature, 369:151-154 (1994).
J. Altman, et al.,Proc. Natl. Acad. Sci, USA, 90:10330-10334 (1993).
L. Stern, et al.,Nature, 368:215-221 (1994).
S. Sharma, et al.,Proc. Natl. Acad. Sci. USA, 88:11465-11469 (1991).
J. Guery, et al.,Critical Reviews in Immunology, 13(3/4):195-206 (1993).
M. Nicolle, et al.,J. Clin. Invest., 93:1361-1369 (1994).
D. Harlan, et al.,Proc. Natl. Acad. Sci. USA, 91:3137-3141 (1994).
E. Evahold, et al.,Immunology Today, 14(12):602-609 (1993).
R. Chicz, et al.,Immunology Today, 15(4):155-160 (1994).
R. Tisch, et al.,Proc. Natl. Acad. Sci. USA, 91:437-438 (1994).
Science, 259:1691-1692 (1993).
J. Ulmer, et al.,Science, 259:1745-1749 (1993).
H. Ploegh, et al.,Nature, 364:16-17 (1993).
J. Brown, et al.,Nature, 364:33-39 (1993).
D. O'Sullivan, et al.,Journal of Immunology, 147:2663-2669 (1991).
J. Hammer, et al.,J. Exp. Med., 176:1007-1013 (1992).
L. Stern, et al.,Cell, 68:465-477 (1992).
K. Webber, et al.,Molecular Immunology, 32: 249 (1995).
Y. Reiter, et al.,The Journal of Biological Chemistry, 269: 18327 (1994).
K. O'Neil, et al.Science, 249: 774-778.
Rhode, P.R., et al.,Single-Chain MHC Class II Molecules Induce T Cell Activation and Apoptosis, The American Association of Immunologists, 1996.
U.S. Appl. No. 08/283,302, filed Jul. 29, 1994, Wong et al.
U.S. Appl. No. 08/382,454, filed Feb. 1, 1995, Rhode et al.
U.S. Appl. No. 09/766,378, filed Jan. 19, 2001, Rhode et al.
U.S. Appl. No. 09/900,379, filed Jul. 6, 2001, Rhode et al.
Burkhardt Martin
Jiao Jin-An
Rhode Peter R.
Wong Hing C.
Altor Bioscience Corporation
Chan Christina
Corless Peter F.
Edwards Angell Palmer and Dodge LLP
VanderVegt F. Pierre
LandOfFree
MHC complexes and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with MHC complexes and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and MHC complexes and uses thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3621100