MHC complexes and uses thereof

Details MHC complexes and uses thereof MHC complexes and uses thereof

2006-07-11

2006-07-11

Chan, Christina (Department: 1644)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Glycoprotein, e.g., mucins, proteoglycans, etc.

C530S324000, C530S325000, C530S326000, C530S327000, C530S328000, C530S391100, C530S391700, C530S402000, C530S868000

Reexamination Certificate

active

07074904

ABSTRACT:
The present invention relates to novel complexes of major histocompability complex (MHC) molecules and uses of such complexes. In particular, the invention relates to MHC fusion complexes that contain a MHC molecule with a peptide-binding groove and a presenting peptide covalently linked to the MHC protein. Fusion complexes of the invention are useful for a variety of applications including in vitro screens for identification and isolation of peptides that modulate activity of selected T cells, including peptides that are T cell receptor antagonists and partial agonists, methods of suppressing an immune response of a mammal and methods for inducing an immune response in a mammal.

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