Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-12-13
2009-10-06
Wilson, James O (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C544S251000
Reexamination Certificate
active
07598259
ABSTRACT:
In its many embodiments, the present invention provides tricyclic compounds of formula I (wherein J1-J4, X, and R1-R5are as defined herein) useful as metabotropic glutamate receptor (mGluR) antagonists, particularly as selective metabotropic glutamate receptor 1 antagonists, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds and compositions to treat diseases associated with metabotropic glutamate receptor (e.g., mGluR1) such as, for example, pain, migraine, anxiety, urinary incontinence and neurodegenerative diseases such Alzheimer's disease.
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Burnett Duane A
Domalski Martin S.
Korakas Peter
Matasi Julius J
Qiang Li
Banerjee Krishna G.
Kalyanaraman Palaiyur S.
Leeser Erich A
MacMillan Keith D.
Schering Corporation
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