Mevalonate synthesis enzymes

Multicellular living organisms and unmodified parts thereof and – Plant – seedling – plant seed – or plant part – per se

Reexamination Certificate

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C435S006120, C435S069100, C435S468000, C435S419000, C435S252300, C435S320100, C435S183000, C530S370000, C536S023600, C800S278000

Reexamination Certificate

active

07135622

ABSTRACT:
This invention relates to an isolated nucleic acid fragment encoding a mevalonate synthesis enzyme. The invention also relates to the construction of a chimeric gene encoding all or a portion of the mevalonate synthesis enzyme, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of the mevalonate synthesis enzyme in a transformed host cell.

REFERENCES:
Douglas J. McGarvey et al., The Plant Cell, vol. 7:1015-1026, Jul. 1985, Terpenoid Metabolism.
Akira Honda et al., Journal of Lipid Research, vol. 39:44-50, 1998, Down-regulation of cholesterol biosynthesis in sitosterolemia: diminished activities of acetoacetyl-CoA thiolase, 3-hydroxy-3-methylglutaryl-CoA synthase, reductase, squalene synthase, and 7-dehydrocholesterol Δ7-reductase in liver and mononuclear leukocytes.
Rodney Croteau et al., Archives of Biochemistry and Biophysics, vol. 271:524-535, Jun. 1989, Geranyl Pyrophate Synthase: Characterization of the Enzyme and Evidence That This Chain-Length Specific Prenyltransferase Is Associated with Monoterpene Biosynthesis in Sage.
Thomas J. Bach, Lipids, vol. 21:82-88, 1986, Hydroxymethylglutaryl-CoA Reductase, a Key Enzyme in Phytosterol Synthesis?.
Thomas J. Bach, Plant Physiol. Biochem. vol. 25:163-178, 1987, Synthesis and metabolism of mevalonic acid in plants.
Montserrat Enjuto et. al., Proc. Natl. Acad. Sci. USA, vol. 91:927-931, 1994,Arabidopsis thalianacontains two differentially expressed 3-hydroxy-3-methylglutaryl-CoA reductase genes, which encode microsomal forms on the enzyme.
Lenka Biardi et. al., The Journal of Biochemical Chemistry, vol. 271:1784-1788, 1996, Compartmentalization of Cholesterol Biosynthesis.
National Center for Biotechnology Information General Identifier No. 5531937, Jul. 20, 1999, Moon, J. S. et. al., Identification of maize acetoacetyl CoA thiolase from developing maize embryo.
National Center for Biotechnology Information General Identifier No. 5607829, Jul. 27, 1999, Walbot, V., Maize ESTs from various cDNA libraries sequenced at Stanford University.
National Center for Biotechnology Information General Identifier No. 6021192, Mar. 30, 2000, Walbot, V., Maize ESTs from various cDNA libraries sequenced at Stanford University.
National Center for Biotechnology Information General Identifier No. 5607308, Jul. 27, 1999, Yamamoto, K. et. al., Rice cDNA from callus. (1998).
National Center for Biotechnology Information General Identifier No. 3763023, Oct. 19, 1998, Sasaki, T. et. al., Rice cDNA from panicle.
National Center for Biotechnology Information General Identifier No. 426049, Jul. 8, 1999, Sasaki, T. et. al., Rice cDNA from callus.
National Center for Biotechnology Information General Identifier No. 3107208, May 4, 1998, Uchimlya, H., On nucleotide sequence of Oryza sativa.
National Center for Biotechnology Information General Identifier No. 2443029, Sep. 29, 1997, Sasaki, T. et. al., Rice cDNA from immature leaf including apical meristem.
National Center for Biotechnology Information General Identifier No. 5761368, Dec. 13, 1999, Shoemaker, R. et. al., Public Soybean EST Project.
Andreas P. Russ et. al., Biochimica et Biophysical Acta. vol. 1132:329-331, 1992, Amplification and direct sequencing of a cDNA encoding human cytosolic 3-hydroxy-3-methylglutaryl-coenzyme A synthase.
National Center for Biotechnology Information General Identifier No. 5030550, Feb. 2, 2000, Walbot, V., Maize ESTs from various cDNA libraries sequenced at Stanford University.
National Center for Biotechnology Information General Idenifier No. 6012290, Oct. 5, 1999, Walbot, V., Maize ESTs from various cDNA libraries sequenced at Stanford University.
National Center for Biotechnology Information General Identifier No. 5901402, Sep. 15, 1999, Walbot, V., Maize ESTs from various cDNA libraries sequenced at Stanford University.
National Center for Biotechnology Information General Identifier No. 3760977, Oct. 19, 1998, Sasaki, T. et. al., Rice cDNA from Callus.
National Center for Biotechnology Information General Identifier No. 2427448, Sep. 22, 1997, Sasaki, T. et. al., Rice cDNA from panicle at flowering stage.
National Center for Biotechnology Information General Idenifier No. 428081, Jul. 8, 1999, Minobe, Y. et. al., Rice cDNA from root.
National Center for Biotechnology Information General Identifier No. 454498, Jul. 8, 1999, Sasaki, T. et. al., Rice cDNA from callus.
National Center for Biotechnology Information General Identifier No. 1542941, Sep. 13, 1996, Vollack, K. U. et. al., Cloning of a cDNA encoding cytosolic acetoacetyl-coenzyme A thiolase from radish by functional expression inSaccharomyces cerevisiae.
National Center for Biotechnology Information General Indentifier No. 5531937, Jul. 20, 1999, Moon, J. S. et. al., Identification of maize acetoacetyl Coa thiolase from developing maize embryo.
National Center for Biotechnology Information General Identifier No. 1708236, Oct. 1, 1996, Montamat, F. et. al., Isolation and characterization of a cDNA encodingArabidopsis thaliana3-hydroxy-3-methylglutary-coenzyme A synthase.
Vollack et al. Plant Physiol. vol. 111, No. 4:1097-1107 (1996).
Florence Montamat et. al., Gene, vol. 167:197-201, 1995, Isolation and characterization of a cDNA encodingArabidopsis thaliana3-hydroxy-3-methylglutaryl-coenzyme A synthase.
Hiroshi Watanabe et. al., Tohuku J. Exp. Med., vol. 184:29-38, 1998, Practical Assay Method of Cytosolic Acetoacetyl-CoA Thiolase by Rapid Release of Cytosolic Enzymes from Cultured Lymphocytes using Digitonin.
Hubert Scharnagl et. al., Journal of Lipid Research, vol. 36:622-627, 1995, A novel assay for cytosolic 3-hydroxy-3-methylglutaryl-coenzyme A synthase activity using revered-phase ion-pair chromatography: demonstration that Lifibrol (K12.128) modulates the enzyme activity.
Russel et. al., Journal of Molecular Biology, vol. 244:332-350, 1994.
National Center for Biotechnology Information General Identifier No. 16417956, Oct. 25, 2001, Hallahan, D.L. and Keiper-Hrynko, N.M., Genes involved in the biosynthesis of isopentenyl diphosphate in the rubber treeHevea brasiliensis.

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