Metorphamide--a novel morphine-like peptide

Details Metorphamide--a novel morphine-like peptide Metorphamide--a novel morphine-like peptide

1983-06-24

1984-12-25

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

2601125E, A61K 3700, C07C10352

Patent

active

044903634

ABSTRACT:
A morphine-like amidated opioid octapeptide metorphamide having the struce Try-Gly-Gly-Phe-Met-Arg-Arg-Val-NH.sub.2 has been isolated from bovine caudate nucleus extracts and synthesized by solid phase peptide synthesis methods. Metorphamide is thus far the only natural opioid peptide having a high .mu.-binding activity.

REFERENCES:
European Journal of Pharmacology 85, (1982), 355-356.
Proc. Natl. Acad. Sci. 78, (1981), 1962-1966.

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