Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2008-01-15
2008-01-15
Schnizer, Richard (Department: 1635)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S025300, C514S04400A
Reexamination Certificate
active
07319145
ABSTRACT:
The present invention provides methylenetetrahydrofolate reductase (MTHFR) inhibitors for use in selective inhibition of cancer cell growth in a mammal. These inhibitors can be a small molecule, an antisense oligonucleotide, a ribozyme, a triple helix forming oligonucleotide, an anti-MTHFR antibody or fragment thereof, an MTHFR mutant or a fragment of MTHFR. The present invention further provides nucleic acids encoding an inhibitor of MTHFR, and vectors comprising these nucleic acids. Also encompassed by the present invention are methods of using the MTHFR inhibitors for selective inhibition of cancer cell growth, and pharmaceutical compositions comprising the MTHFR inhibitors.
REFERENCES:
patent: 3687808 (1972-08-01), Merigan, Jr. et al.
patent: 5512438 (1996-04-01), Ecker
patent: 5972614 (1999-10-01), Ruano et al.
patent: 5981279 (1999-11-01), Weiss
patent: 5998206 (1999-12-01), Cowsert
patent: 6008221 (1999-12-01), Smith et al.
patent: 6074821 (2000-06-01), Rozen et al.
patent: 6566064 (2003-05-01), Shiraki et al.
patent: 2002/0037507 (2002-03-01), WalkerPeach et al.
patent: 2005/0101555 (2005-05-01), Zhang et al.
patent: 9410620.0 (1995-05-01), None
patent: WO 88/04300 (1988-06-01), None
patent: WO95/33054 (1995-12-01), None
patent: WO00/04194 (2000-01-01), None
patent: WO00/52205 (2000-09-01), None
patent: WO 00/52205 (2000-09-01), None
Branch TIBS 1998, vol. 23, p. 45-50.
Opalinska et al. Nature Reviews Drug Discovery, 2002, vol. 1, p. 503-514.
Matthews et al. Biochemistry, 1979, vol. 18, p. 4845-4851.
Kutzbach et al. Biochimica et Biophysica Acta, 1967, vol. 139, p. 217-220.
Alberts et al. (1983) Molecular Biology of The Cell, Garland Publishing Inc., New York, pp. 411-415.
Been and Cech (1986) Cell 47:207-216.
Bitko and Barik (2001) BMC Microbiol. 1:34.
Branch A. (1998) TIBS 23 pp. 45-50.
Bufalo et al., (1996) British J. Canc. 74:387-393.
Burton D. R. (1991) Proc. Natl. Acad. Sci. USA, 88:10134-10137.
Cech (1988) JAMA 260:3030.
Clarke et al. (1991) N. Engl. J. Med. 324:1149-1155.
Cole, S. P. et al. (1984) Mol. Cell Biol. 62:109-120.
Cote, R. J. et al. (1983) Proc. Natl. Acad. Sci. USA, 80:2026-2030.
Crooke et al. (1996) J. Pharmacol. Exp. Ther. 277:923-937.
Dean et al., (1996) Cancer Res. 56:3499-3507.
Elbashir et al. (2001) Nature 411:494-498.
Englisch et al. (1991) Angewandte Chemie, Int. Ed., 30:613.
Goding (1980) J. Imm. Meth. 39:285-308.
Hasegawa et al., (1998) Int. J. Cancer 76:812-816.
Haseloff and Gerlach (1988) Nature 334:585.
Huse, W. D. et al. (1989) Scienc,e 246:1275-1281.
Jefferies (1989) Nucleic Acids Research 17:1371.
Kabanov et al. (1990) FEBS Lett. 259:327-330.
Kim et al. (1987) Proc. Natl. Acad. Sci. USA 84:8788.
Kohler, G. et al. (1975) Nature 256:495-497.
Kozbor, D. et al. (1985) J. Immunol. Methods 81:31-42.
Krieg et al (1995) Nature 374:546-549.
Kutzbach et al. (1967) Biochim. Biophysica. Acta. 139:217-220.
Letsinger et al (1989) Proc. Natl. Acad. Sci. USA 86:6553-6556.
Li et al. (1999) Clin. Cancer Res. 5:637-642.
Maddox, D. E. et al. (1983) J. Exp. Med. 158:1211-1216.
Manoharan et al. (1992) Ann. N.Y. Acad. Sci. 660:306-309.
Manoharan et al. (1994) Bioorg. Med. Chem. Let. 4:1053-1060.
Manoharan et al. (1993) Bioorg. Med. Chem. Lett. 3:2765-2770.
Manoharan et al. (1995) Nucleosides and Nucleotides 14:969-973.
Manoharan et al. (1995) Tetrahedron Lett. 36:3651-3654.
Martin et al. (1995) Helv. Chim. Acta. 78:486-504 Abstract only.
Matthews et al. (1979) Biochemistry 18(22):4845-4851.
Mishra et al. (1995) Biochim Biophysica Acta. 1264:229-237.
Morrison, S. L. et al. (1984) Proc. Natl. Acad. Sci. 81:6851-6855.
Narayanan, (1994) In Vivo 8: 787-794.
Needleman and Wunsch (1970) J. Mol. Biol. 48:443.
Neuberger, M. S. et al. (1984) Nature 312:604-608.
Nielsen et al. (1991) Science 254:1497-1500.
Oberhauser et al. (1992) Nucl. Acids Res. 20:533-538.
Opalinska et al. (2002) Nature Reviews Drug Discovery 1:503-514.
Orlandi, R. et al. (1989) Proc. Natl. Acad. Sci. 86: 3833-3837.
Pearson and Lipman (1988) Proc. Acad. Natl. Sci. (USA) 85:2444.
Saison-Behamoras et al. (1991) EMBO J. 10:1111-1118.
Sanghvi, Y.S. (1993) Antisense Research and Applications, pp. 289-302 and 276-278, Crooke, S.T. and Lebleu B., ed., CRC Press.
Sekhon et al. (2002) British Journal of Cancer 87:225-230.
Shea et al. (1990) Nucl. Acids. Res. 18:3777-3783.
Smith and Waterman (1981) Adv. Appl. Math. 2:482.
Svinarchuk et al. (1993) Biochimie 75:49-54.
Takeda, S. et al. (1985) Nature 314:452-454.
The Concise Encyclopedia Of Polymer Science and Engineering (1990) pp. 858-859, Kroschwitz, J.I. ed. John Wiley and Sons.
Winter, G. et al. (1991) Nature 349:293-299.
Zamore (2001) Nature Struct. Biol. 8:746-750.
Zaug and Cech (1986) Science 231:470-475.
Zaug et al. (1984) Science 224:574-578.
Zaug et al. (1986) Nature 324:429-433.
Bakker et al. Hyperhomocysteinaemia and associated disease. Pharm. World Sci. (1997) 19:126:132.
Brattstrom et al. Plasma Homocysteine and Methionine Tolerance in Early-Onset Vascular Disease. Haemostasis (1989) 19:35-44.
Chen et al. A Methylenetetrahydrofolate Reductase Polymorphism and the Risk of Colorectal Cancer. Cancer Research (1996) 56:4862-4864.
Chen et al. MTHFR Polymorphism, Methyl-Replete Diets and the Risk of Colorectal Carcinoma and Adenoma among U.S. Men and Women: An Example of Gene-Environment Interactions in Colorectal Tumorigenesis. American Society for Nutritional Sciences (1996) p. 560S-564S.
Engbersen et al. Thermolabile 5,10-Methylenetetrahydrofolate Reductase as a Cause of Mild Hyperhomocysteinemia. Am. J. Hum. Genet. (1995) 56:142-150.
Goyette et al. Seven Novel Mutations in the Methylenetetrahydrofolate Reductase Gene and Genotype/Phenotype Correlations in Severe Methylenetetrahydrofolate Reductase Deficiency. Am. J. Hum. Genet. (1995) 56: 1052-1059.
Goyette et al. Severe Mild Mutations in cis for the Methlenetetrahydrofolate Reductase (MTHFR) Gene, and Description of Five Novel Mutations in MTHFR. Am. J. Hum. Genet. (1996) 59:1268-1275.
Grandone et al. Factor V Leiden, C>T MTHFR Polymorphism and Genetic Susceptibility to Preeclampsia. Thromb. Haemost (1997) 77:1052-1054.
Greico. Homocystinuria: pathogenetic mechanisms. Am. J. of Med. Sci. (1977) 273:120-132.
Third Wave Technologies Launches Third Pharmacogenetic Product: Oligonucleotide Sets and Assay Controls Specific for MTHFR Mutation (Madison, WI—Dec. 9, 1999)—News Release—Third Wave Technologies.
van der Put et al. A Second Common Mutation in the Methylenetetrahydrofolate Reductase Gene: An Additional Risk Factor for Neural-Tube Defects? Am. J. Hum. Genet. (1998) 62:1044-1051.
Rozen, R. Molecular Genetics of Methylenetetrahydrofolate Reductase Deficiency, J. Inher Metab. Dis. (1996) 16:589-594.
Agrawal et al., “Antisense Therapeutics: Is it as simple as complementary base recognition?” Molecular Medicine Today 6, 72-81 (2000).
Bennett, F.C. et al., Pharmacology of Antisense Therapeutic Agents: Methods in Molecular Medicine: Antisense Therapeutics, 13-46 (1996).
Flanagan W.M. et al ., “Cellular Penetration and Antisense Activity by a Phenioxazine -Substituted Heptancleotide” Research , 1-5 (1998).
Green D.W. et al., “Antisense Oligonucleotides: An evolving Technology for the Modulation of Gene Expression in Human Disease.” American College of Surgeons, 1, 93-103 (2000).
Jen K-Y et al., Suppression of Gene Expression by targeted disruption of messanger RNA: Available Options and Current Strategies, 18, 307-319 (2000).
Ma et al., “Synthetic Oligonucleotides as Therapeutices: The Coming of Age.” Biotechnology Annual Review 5, 155-196 (2000).
Agrawal et al., 1999.Biochimica et Biophysica Acta1489:53-68.
Akar et al., 2000.Throm. Res. 97:163-167.
Araki et al., 1987. J. Chromatography 422:43-52.
Arlnami et al., 1997. Amer. J. of Medical Genetics 74:526-528.
Boushey et al., 1995. JAMA 274:1049-1057.
Chapman et al. 1998. Stroke. 29:1401-1404.
Chen et al., 1998. Carcinogenesis 19(12):2129-2132.
Christensen et al., 1997. Arteriosclerosis, Thrombosis, and Vascular Biology 17:569-573.
Esteller et al., 1997. Carcinogenesis 18
Rozen Rima
Sekhon Jaspreet
Law Offices of Albert Wai-Kit Chan PLLC
Rozen Rima
Schnizer Richard
Vivlemore Tracy
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