Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1994-06-03
1996-11-12
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
546 21, 546 22, 546 23, A61K 3144, A61K 31445, C07F 958, C07F 959
Patent
active
055740243
ABSTRACT:
The present invention involves novel methylene phosphonoalkylphosphinic acids, pharmaceutical compositions containing such compounds, and methods for treating or preventing pathological conditions characterized by abnormal calcium and phosphate metabolism by administering such compounds to a human or lower animal.
REFERENCES:
patent: 3553314 (1971-01-01), Francis
patent: 3683080 (1972-08-01), Francis
patent: 3846420 (1974-11-01), Wollmann et al.
patent: 3899496 (1975-08-01), Schindler et al.
patent: 3941772 (1976-03-01), Polger et al.
patent: 3957160 (1976-05-01), Ploger et al.
patent: 3979385 (1976-09-01), Wollmann et al.
patent: 3988443 (1976-10-01), Ploger et al.
patent: 4113861 (1978-09-01), Fleisch et al.
patent: 4117090 (1978-09-01), Ploger
patent: 4134969 (1979-01-01), Schmidt-Dunker
patent: 4267108 (1981-05-01), Blum et al.
patent: 4304734 (1981-12-01), Jary et al.
patent: 4407761 (1983-10-01), Blum et al.
patent: 4469686 (1984-09-01), Andrews
patent: 4608368 (1986-08-01), Blum et al.
patent: 4621077 (1986-11-01), Rosini et al.
patent: 4687767 (1987-08-01), Bosies et al.
patent: 4687768 (1987-08-01), Benedict et al.
patent: 4711880 (1987-12-01), Stahl et al.
patent: 4719203 (1988-01-01), Bosies et al.
H. G. Henning et al., "Methylene-bis-phosphonic Acid Ester and Methylene-bis-phosphinic Acid Ester", 5 Z. Chem. 419 (1965).
A. N. Pudovik et al., "Reactions of Acid Ethylphosphonous and Phosphorothious Esters with Carbonylphosphonic Esters and 2,3-Butanedione", 37 Z. Obs. Khim. 876 (1967).
A. N. Pudovik et al., "Phosphonate-phosphate Rearrangement of Esters of Hydroxyalkylphosphonic Acids", Z. Obs. Khim. 143 (1968).
A. N. Pudovik et al., "Synthesis and Reactions of (2-Cyanovinyl)phosphonic Esters", 38 Z. Obs. Khim. 292 (1968).
W. Ploger et al., "Preparation of 1-Aminoalkane-1, 1-diphosphonic Acids", 389 Z. Anorg. Allg. Chem. 119 (1972).
W. F. Gilmore et al., "Base-catalyzed Condensation of Aldehydes with Ethyl Bis(diethylphosphonomethyl)phosphinate", 38 J. Org. Chem. 1423 (1973).
G. V. Romanov et al., "Thermodynamic and Kinetic Characteristics of Phosphonate-Phosphate Rearrangement", 43 Z. Obs. Khim. 2378 (1973).
Z. S. Zovikova et al., "Addition of Tetraethyl Pyrophosphite and of Tetraethyl Isohypophosphate to Compounds Containing an Activated Double Bond", 44 Z. Obs. Khim. 276 (1974).
Z. S. Zovikova et al., "Reactions of Methyl Bis(diethoxy-phosphino)acetate with Alkyl Halides", 48 Z. Obs. Khim. 757 (1978).
J. Oleksyszyn et al., "Phosphoranaloge von Aminosauren und Peptiden: Phosphon-und Phosphinanaloge von Cycloleucin", 32 Chimia 253 (1978).
L. Maier, "Herstellung und Eigenschaften von Aminomethylendiphosphinaten und -diphosphonaten, RR.sup.1 NCH[P(O)R.sup.2 (OR.sup.3)].sup.2 und Derivitaen", 11 Phosphorus und Sulfur 311 (1981).
L. Maier, "Advances in the Chemistry of Aminophosphinic Acids", 14 Phosphorus and Sulfur 295 (1983).
Francis et al., "Chemical, Biochemical, and Medicinal Properties of the Diphosphonates", The Role of Phosphonates in Living Systems, 55 (Hildebrand, ed., 1983).
Y. Surh et al., "Technetium-99m Labeled Phosphonic Acid Analog of Serine: Bone Uptake", 27 J. Nuclear Medicine, 847 (1986).
W. F. Gilmore et al., "Base-catalyzed Condensation of Bis(diethylphosphono-methyl)-phosphinic Amides with Aldehydes", 29 Phosphorus and Sulfur, 287 (1987).
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