Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-03-06
2007-03-06
Aulakh, Charanjit S. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S077000
Reexamination Certificate
active
10487862
ABSTRACT:
17-methylene-4-azasteroid compounds of formula I:wherein R20denotes fluoro, chloro or bromo R20adenotes hydrogen, R10and R4each denote a hydrogen atom or a methyl group, and R1and R2each denote a hydrogen atom or together denote an additional bond, are useful for treating diseases or conditions caused by excessive androgen levels, such as acne, prostate diseases, alopecia and hirsutism, as well as gynecological conditions. Methods of synthesizing the new 17-methylene-4-azasteroid compounds are described.
REFERENCES:
patent: 5763361 (1998-06-01), Harris et al.
patent: 93 15104 (1993-08-01), None
patent: 97 15558 (1997-05-01), None
patent: 98 33506 (1998-08-01), None
patent: 02 00681 (2002-01-01), None
patent: 02 19971 (2002-03-01), None
Rasmusson et al: “Azasteroids as Inhibitors of Rat . . . ” Journal of Medicinal Chemistry, American Chemical Society, Washington, US, vol. 27, No. 12, Dec. 1, 1984, pp. 1690-1701.
Brooks et al: “5alpha-Reductase Inhibitory and Anti . . . ”Steroids: Structure, Function, and Regulations, Elsevier Science Publishers, New York, NY US, vol. 47, No. 1, 1986, pp. 1-19.
Rasmusson et al: “Azasteroids: Structure-Activity Relationships . . . ” Journal of Medicinal Chemistry, American Chemical Society, Washington, US, vol. 29, No. 11, Nov. 1, 1986, pp. 2298-2315.
J.K.L. Tan: “Oral Contraceotives in the Treatment of Acne” Skin Therapy Letter, vol. 6, No. 5, Feb. 2001, pp. 1-8. (in English).
J.A. Miller et al: “Anti-Androgen Treatment in . . . ” Brotish Journal of Dermatology 1986, 114, pp. 705-716. (in English).
R. Greenwood et al: “Acne: Double Blind Clinical and . . . ” British Medical Journal vol. 291, Nov. 2, 1985, pp. 1231-1235 (in English).
Julianne Imperato-McGinley et al: “The Androgen Control . . . ” Journal of Clinical Enfdocrinology and Metabolism, vol. 76, No. 2, pp. 524-528, 1993.
“Behandlung Der Alopecia. . . ”http:haarerkrankungen.de/therapie/Aga—finasteridtherapie.htm, Admitted Prior Art (With English Translation).
Droescher Peter
Elger Walter
Hillisch Alexander
Menzenbach Bernd
Schoellkopf Klaus
Aulakh Charanjit S.
Schering AG
Striker Michael J.
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