Methylcyclohexyl-O-anisylphosphine

Details Methylcyclohexyl-O-anisylphosphine Methylcyclohexyl-O-anisylphosphine

1978-09-05

1981-10-13

Sneed, Helen M. S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus containing

252431P, 260429R, C07F 950

Patent

active

042949890

ABSTRACT:
Process for the homogeneous catalytic hydrogenation of .beta.-substituted-.alpha.-acylamido-acrylic acids which yields, after hydrogenation, an optically active mixture. The process comprises the hydrogenation of .beta.-substituted-.alpha.-acylamido-acrylic acids in the presence of an optically active coordinated metal complex hydrogenation catalyst, in which the metal is selected from the group consisting of rhodium, iridium, ruthenium, osmium, palladium and platinum.
This process is a generalized process for any asymmetric hydrogenation of .beta.-substituted-.alpha.-acylamido-acrylic acids in which one .alpha.-amino acid enantiomorph is the desired end-product. It is especially useful for the preparation of .alpha.-amino acids found in nature which possess optical activity and which have a hydrogen attached to the asymmetric center.
This invention also relates to new optically active coordinated metal complex hydrogenation catalysts.

REFERENCES:
Kosolapoff, Organophosphorus Compounds, John Wiley & Sons, Inc., N. Y., p. 37, (1950).

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