Methylation of de-A steroids

Details Methylation of de-A steroids Methylation of de-A steroids

1975-06-23

1978-05-02

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260338, 2603405AS, 2603409A, 2603407, 260586E, 260586R, C07D26106, C07D31708, C07C 4954, C07C 4960

Patent

active

040874362

ABSTRACT:
Treatment of de-A steroids with a methylation agent at extremely low temperatures, i.e., below -50.degree. C. produces corresponding 10.beta.-methyl-.DELTA..sup.9(11) -deA steroids with a high 10.beta. to 10.alpha. isomer ratio. A number of the product 10.beta.-methyl-.DELTA..sup.9(11) -deA steroids are novel compounds. They are useful as intermediates in the synthesis of known medicinally valuable steroids.

REFERENCES:
patent: 3010974 (1976-11-01), Barkley
J. E. McMurry, Ph.D Thesis, Columbia Univ. N.Y. (1967) pp. 69 and 70.

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