Methylated tat polypeptides and methods of use thereof

Details Methylated tat polypeptides and methods of use thereof Methylated tat polypeptides and methods of use thereof

2008-08-12

2011-10-11

Parkin, Jeffrey S. (Department: 1648)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

C424S208100, C530S345000

Reexamination Certificate

active

08034350

ABSTRACT:
The present invention provides isolated methylated Tat peptides; and compositions comprising the peptides. The present invention further provides isolated antibodies specific for a Lys-51-methylated Tat polypeptide. Also provided are methods of identifying agents that inhibit Lys-51 methylation of a Tat polypeptide. The present invention further provides methods of treating an immunodeficiency virus infection in a mammalian subject.

REFERENCES:
patent: 7589167 (2009-09-01), Zhou et al.
patent: 2004/0247614 (2004-12-01), Dorr et al.
Boulanger, M.-C., et al., 2005, Methylation of Tat by PRMT6 regulates human immunodeficiency virus type 1 gene expression, J. Virol. 79(1):124-131.
Wolfsberg, T. G. and T. L. Madden. 1999. Sequence similarity searching using the Blast family of programs. Curr. Prot. Prot. Sci. 2.5.1-2.5.29.
Dorr et al. “Transcriptional synergy between Tat and PCAF is dependent on the binding of acetylated Tat to the PCAF bromodomain.” EMBO J. Jun. 3, 2002;21(11):2715-23.
Nishioka et al. “Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation.” Genes Dev. Feb. 15, 2002;16(4):479-89.

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