Methuselah gene, compositions and methods of use

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

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C530S388100, C530S389100, C530S350000, C435S007100

Reexamination Certificate

active

06906181

ABSTRACT:
Disclosed are polypeptides and polynucleotides having stress and life span modulating activity. The polypeptides and polynucleotides are useful in identifying and modulating stress-associated disorders.

REFERENCES:
Zou et al. Proc. Nat. Acad. Sci. 2000, vol. 97, pp. 13726-13731.
Hamm J. Biol. Chem., 1998, vol. 278, pp. 669-672.
IMAGE consortium, Accession No. AA250332, Mar. 12, 1997.
Lin et al., Extended Life-Span and Stress Resistance in the Drosophila Mutant methuselah. Science 1998, vol. 282, pp. 943-946.
Arking et al., Elevated Paraquat Resistance Can Be Used as a Bioassay for Longevity in a Genetically Based Long-Lived Strain of Drosophila Dev Genet 1991 vol 12 pp. 362-370.

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