Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1996-08-05
1999-05-11
Wilson, James O.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 253, 536 2531, 536 2534, 536 2626, 536 266, 536 267, 536 268, 536 276, 536 278, 536 2781, 536 281, 536 285, 536 2853, 536 2854, 536124, C07H1/00;19/00;21/00
Patent
active
059028793
ABSTRACT:
Moieties, including a 2'-methoxyoxalamido and N-succinimido moieties, were incorporated into a compound, particularly an oligonucleotide molecule. The moieties were shown to be useful precursors for the post synthetic introduction of various functional additives.
REFERENCES:
patent: 5112962 (1992-05-01), Letsinger et al.
patent: 5466786 (1995-11-01), Buhr et al.
patent: 5547835 (1996-08-01), Koster
V.A. Efimov, "Recent Developments in the Synthesis of Oligonucleotides, Their Analogues and Conjugates", Nucleic Acids Symposium (Aug. 6-11, 1995).
N.N. Polushin, "Synthesis of Functionally Modified Oligonucleotides Through 2'-Methoxyoxalamide-2'-Deoxyuridine Containing Precursors", Nucleic Acids Symposium (Aug. 6-11, 1995).
N. N. Polushin, "Synthesis of Functionally Modified Oligonucleotides from Methoxyoxalamido Precursors", Tetrahedron Letters, vol. 37, No. 19, pp. 3231-3234, (1996).
N. N. Polushin, "Synthesis of Oligonucleotides Containing 2'-Azido- and 2'-Amino-2'-deoxyuridine Using Phosphotriester Chemistry", Tetrahedron Letters, vol. 37, No. 19, pp. 3227-3230, (1996).
N. Herbert, "Synthesis of N-Substituted Hydroxyprolinol Phosphoramidites for the Preparation of Combinatorial Libraries", Tetrahedron Letters, vol. 35, No. 51, pp. 9509-9512, (1994).
P. W. Davis, "Drug Leads from Combinatorial Phosphodiester Libraries", J. Med. Chem., vol. 38, pp. 4363-4366, (1995).
A. M. MacMillan, "Synthesis of Functionally Tethered Oligodeoxynucleotides by the Convertible Nucleoside Approach", J. Org. Chem, vol. 55, pp. 5931-5933, (1990).
L. Biegelman et al., "Synthesis of 2'-modified Nucleotides and their Incorporation into Hammerhead Ribozymes", Nucleic Acids Research, vol. 23, No. 21, pp. 4434-4442, (1995).
N. N. Polushin et al., "Synthesis and Characterization of Imidazoyl-Linked Synthons and 3'-Conjugated Thymidine Derivatives", Journal of Organic Chemistry, vol. 58, pp. 4606-4613, (1993).
R. H. Alul, "Oxalyl-CPG: a labile support for synthesis of sensitive oligonucleotide derivatives", Nucleic Acids Research, vol. 19, No. 9, pp. 1527-1532, (1991).
A. M. MacMillan et al., "Engineering Tethered DNA Molecules by the Convertible Nucleoside Approach", Tetrahedron Letters, vol. 47, No. 14/15, pp. 2603-2616, (1991).
A. E. Ferentz et al., "Aminolysis of 2'-Deoxyinosine Aryl Ethers: Nucleoside Model Studies for the Synthesis of Functionally Tethered Oligonucleotides", Nucleosides & Nucleotides, vol. 11, No. 10, pp. 1749-1763, (1992).
F. Benseler et al., "Synthesis of Suitably-protected Phosphoramidites of 2'-Fluoro-2'-Deoxyguanosine and 2'-Amino-2'-Deoxyguanosine for Incorporation into Oligoribonucleotides", Nucleosides & Nucleotides, vol. 11, No. 7, pp. 1333-1351, (1992).
I. P. Smirnov et al., "Sequencing Oligonucleotides by Exonuclease Digestion and Delayed Extraction Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry", Analytical Biochemistry, vol. 288, pp. 19-25, (1996).
J. Goodchild, "Conjugates of Oligonucleotides and Modified Oligonucleotides: A Review of Their Synthesis and Properties", Perspectives in Bioconjugate Chemistry, pp. 77-99, (1993).
V.A. Efimov et al., "New Activators for the Phosphoramidite Oligonucleotide Synthesis", vol. 22, No. 2, (1996).
Fidelity Systems, Inc.
Wilson James O.
LandOfFree
Methoxyoxalamido and succinimido precursors for nucleophilic add does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methoxyoxalamido and succinimido precursors for nucleophilic add, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methoxyoxalamido and succinimido precursors for nucleophilic add will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-246131