Methods using the Staphylococcus aureus glycyl tRNA synthetase c

Details Methods using the Staphylococcus aureus glycyl tRNA synthetase c Methods using the Staphylococcus aureus glycyl tRNA synthetase c

1997-01-31

2000-03-14

Hobbs, Lisa J.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

435183, 514 12, 702 19, 702 22, C12Q 170, C12N 900, A61K 3800

Patent

active

06037117&

ABSTRACT:
A novel Staphylococcus glycyl tRNA synthetase crystalline structure is identified. Also disclosed are methods of identifying inhibitors of these synthetases and/or active sites, and inhibitors identified by these methods.

REFERENCES:
Niyomporn, et al., "Biosynthesis of the Peptidoglycan of Bacterial Cell Walls", J. Biol. Chem., vol. 243, No. 4, pp. 773-778, (1968).
Niyomporn, et al., "Glycyl-tRNA Synthetase (Staphylococcus aureus)", Meth. Enzymol., vol. 17, pp. 966-970, (1971).
Belrhali, et al., "Crystal Structures at 2.5 Angstrom Resolution of Seryl-tRNA Synthetase Complexed with two Analogs of Seryl Adenylate", Science, vol. 263(5152), pp. 1432-1436, (1994).
Ueda, et al., "X-ray Crystallographic Conformational Study of 5'-O-[N-(L-alanyl)-sulfamoyl]adenosine, A Substrate Analog for Alanyl-tRNA Synthetase.", Biochim. Biophys. Acta, vol. 1080(2), pp. 126-134, (1991).
Logan, et al., "Crystal Structure of Glycyl-tRNA Synthetase from Thermus Thermophilus", EMBO J., vol. 17(17), pp. 4156-4167, (1995).

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