Methods using modified vaccinia virus

Details Methods using modified vaccinia virus Methods using modified vaccinia virus

1995-05-13

1999-10-26

Degen, Nancy

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 9141, 4351723, 4353201, C12N 1500, C12N 1563, C12Q 170

Patent

active

059725974

ABSTRACT:
What are disclosed are methods for modifying the genome of vaccinia virus to produce vaccinia mutants, particularly by the introduction into the vaccinia genome of exogenous DNA; modified vaccinia prepared by such methods; certain DNA sequences and unmodified and genetically modified microorganisms involved as intermediates in such methods; and methods for infecting cells and host animals with such vaccinia mutants to provoke the amplification of exogenous DNA and proteins encoded by the exogenous DNA, including antigenic proteins, by said cells and host animals.

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