Methods using estrogen receptor as a constitutive transcriptiona

Details Methods using estrogen receptor as a constitutive transcriptiona Methods using estrogen receptor as a constitutive transcriptiona

1990-03-30

1993-02-02

Nucker, Christine M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

456501, 435 71, 435 78, C12Q 168

Patent

active

051837366

ABSTRACT:
The invention provides the discovery that estrogen receptor is a constitutive transcriptional activator and a repressor. These activities are lacking in the mutant estrogen receptor. The invention provides assays and methods for determining estrogen binding activity of ligands. The invention also provides therapeutic methods and the detection of pathologies associated with a mutated estrogen receptor.

REFERENCES:
patent: 4711856 (1987-12-01), Spelsberg
patent: 4806464 (1989-02-01), Spelsberg
Mathews et al.: Analytical Strategies for the Use of DNA Probes, Analytical Biochemistry 169, 1-25, Feb. 1988.

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