Methods to screen for transcription factor-coactivator interacti

Details Methods to screen for transcription factor-coactivator interacti Methods to screen for transcription factor-coactivator interacti

1998-04-02

2000-09-12

McKelvey, Terry

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 29, C12Q 168, C12Q 102

Patent

active

061176389

ABSTRACT:
This invention provides methods for modulating gene expression at the transcriptional level. In particular, the methods involve tethering a transcriptional coactivator to a DNA binding domain that is specific for a target nucleic acid sequence and contacting the coactivator with a transcription factor. The transcription factor triggers or represses transcription mediated by the coactivator. Methods for identifying compounds that are able to modulate gene expression are also provided.

REFERENCES:
patent: 5789170 (1998-08-01), Chang et al.
D. Swope et al. "CREB-binding protein activates transcription through multiple domains" Journal of Biological Chemistry (Nov. 8, 1996) 271 (45): 28138-28145.
K.B. Horwitz et al. "Nuclear Receptor Coactivators and Corepressors" Molecular Endocrinology (Oct. 1996) 10 (10): 1167-1177.
Hong et al, PNAS (USA), vol. 93, pp. 4948-4952, May 1996.
Peterson et al, Trends in Biotech, vol. 11, pp. 11-18, Jan. 1993.

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