Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Reexamination Certificate
2007-05-22
2007-05-22
Padmanabhan, Sreeni (Department: 1617)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
C514S649000, C514S651000
Reexamination Certificate
active
09512926
ABSTRACT:
The present invention discloses materials and methods useful to treat sensitivity of endothelially-compromised vascular smooth muscle. In one embodiment, CLC3 blockers, particularly compounds of the Formula I are used to treat sensitivity.
REFERENCES:
patent: 5077601 (1991-12-01), Hatada et al.
patent: 5224538 (1993-07-01), Jacoby
patent: 5470883 (1995-11-01), Stromberg
patent: 5472985 (1995-12-01), Grainger et al.
patent: 5658936 (1997-08-01), Kifor et al.
patent: 5691355 (1997-11-01), Bryant et al.
patent: 5760066 (1998-06-01), Tang
patent: 5770609 (1998-06-01), Grainger et al.
patent: 5795898 (1998-08-01), Brown et al.
patent: 5811447 (1998-09-01), Kunz et al.
patent: 5912805 (1999-06-01), Freuler et al.
patent: 5940269 (1999-08-01), Ko et al.
patent: 5957194 (1999-09-01), Azar
patent: 6015008 (2000-01-01), Kogure et al.
patent: 6054198 (2000-04-01), Bunyan et al.
patent: 6197789 (2001-03-01), Grainger et al.
patent: 96/40098 (1996-12-01), None
Andreas, S., et al., “Characterization of cell volume-sensitive chloride currents in freshly prepared and cultured pancreatic acinar cells from early postnatal rats”,J. of Physiology, 513 (2), 453-465, (Dec. 1, 1998).
Borsani, G., et al., “Characterization of a Human and Murine Gene (CLCN3) Sharing Similarities to Voltage-Gated Chloride Channels and to a Yeast Integral Membrane Protein”,Genomics, 27, pp. 131-141, (1995).
Dick, G.M., et al., “Functional and molecular identification of a novel chloride conductance in canine colonic smooth muscle”,Am. J. of Physiology, 275 (4), Part 1, C940-C950, (Oct. 1998).
Duan, D., et al., “Molecular identification of a volume-regulated chloride channel”,Nature, 390, pp. 417-421, (Nov. 1997).
Kawasaki, M., et al., “Stable and Functional Expression of the CIC-3 Chloride Channel in Somatic Cell Lines”,Neuron, 14, pp. 1285-1291, (Jun. 1995).
Lamb, F.S., “Supplemental Data to 1R01 18L62483-01 CIC-3 Chloride Ion Channels in Vascular Smooth Muscle”,PHS 398(Rev. May 1995), 4 p., (May 1998).
Lamb, F.S., et al., “Chloride ion currents contribute functionally to norepinephrine-induced vascular contraction”,Am. J. Physiol., 275, pp. H151-H160, (1998).
Lamb, F.S., et al., “The endothelium modulates the contribution of chloride currents to noreponephrine-induced vascular contraction”,Am. J. Physiol., 275, H161-H168, (1998).
Liu, B., et al., “Tamoxifen Normalizes the Increase in Vascular Sensitivity Associated with Endothelial Disruption”,FASEB Journal, 13 (4), Part 1, Abstract, p. A49, (Mar. 12, 1999).
Qiu, X.C., et al., “The cardiovascular reactions mediated by TPA and tamoxifen in spinal cord of conscious rats”,Yaoxue Xuebao, 30 (7), 481-485, (1995).
Yamazaki, J., et al., “Functional and Molecular expression of volume-regulated chloride channels in canine vascular smooth muscle cells”,J. of Physiology, 507 (3), 729-736, (Mar. 15, 1998).
Owens “Regulation of Differentiation of Vascular Smooth Muscle Cells,”Physiological Reviews, 1995, 75:487-517.
Ralph, D. J., et al., “The Treatment of Payronie's Disease with Tamoxifen”,British Journal of Urology, 70, Abstract, Database EMBASe on ACS. Accession No. 93001761 (1992) 648-651.
Kim Jennifer
Padmanabhan Sreeni
University of Iowa Research Foundation
Viksnins Harris & Padys PLLP
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