Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2007-01-30
2007-01-30
Chism, B. Dell (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S357000, C514S408000, C514S649000
Reexamination Certificate
active
10456942
ABSTRACT:
Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed. Preferred embodiments of such compounds are of the formulain-line-formulae description="In-line Formulae" end="lead"?Z-linker-Z′ (1)in-line-formulae description="In-line Formulae" end="tail"?or pharmaceutically acceptable salt thereofwherein Z is of the formulawherein A comprises a monocyclic or bicyclic fused ring system containing at least one N and B is H or an organic moiety of 1–20 atoms,Z′ is of the formulain-line-formulae description="In-line Formulae" end="lead"?—Ar(Y)j;in-line-formulae description="In-line Formulae" end="tail"?wherein Ar is an aromatic or heteroaromatic moiety, and each Y is independently a non-interfering substituent and j is 0–3; and“linker” represents a bond, alkylene (1–6C) or may comprise aryl, fused aryl, oxygen atoms contained in an alkylene chain, or may contain keto groups or nitrogen or sulfur atoms.
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DiJ
Abrams Michael J.
Bridger Gary
Calandra Gary B.
Henson Geoffrey W.
MacFarland Ronald T.
Anormed Inc.
Chism B. Dell
Morrison & Foerster / LLP
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