Methods to measure immunosuppressive tacrolimus, sirolimus,...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S007200, C435S007230, C435S007240, C435S007250, C435S007940, C436S517000, C436S518000, C436S522000, C436S523000, C436S538000, C436S174000, C436S177000, C424S009200

Reexamination Certificate

active

07923210

ABSTRACT:
The present invention provides methods, diagnostic assays, and diagnostic kits based on said methods, to determine levels of immunosuppressive complexes containing immunosuppressive drugs tacrolimus, sirolimus and cyclosporine A separately and in combination, formed in the blood of a drug-treated patient or in a patient candidate to immunosuppressive drug therapy. These methods, assays and kits are especially useful when using automated systems.

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