Methods to increase transgene expression from...

Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus

Reexamination Certificate

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Details

C424S093100, C424S093400, C424S185100, C424S234100, C424S248100, C530S300000, C530S350000, C536S023100, C536S023700

Reexamination Certificate

active

07608256

ABSTRACT:
Bacterial delivery systems with improved transgene expression are provided. The recombinant bacterial delivery systems deliver transgenes of interest and suppressors of the eukaryotic Type I interferon response to eukaryotic cells. Suppression of the eukaryotic Type I interferon response allows improved expression of the encoded transgene.

REFERENCES:
patent: 2004/0077090 (2004-04-01), Short
patent: 2007/0160609 (2007-07-01), Maroun
patent: 2007/0207526 (2007-09-01), Coit

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