Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Reexamination Certificate
2006-12-12
2006-12-12
Shibuya, Mark (Department: 1639)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
C424S184100, C435S007100
Reexamination Certificate
active
07147858
ABSTRACT:
A method of improving specific immune responses to small immunogens, haptens, has been developed by changing the linkage between the hapten and carrier being used for immunization. High affinity antibodies to the hapten cotinine have been produced using this method. Antibodies to a glycated protein have also been developed, utilizing an immunogen which is composed of a glycated peptide mimic of the glycated peptide sequence which is the target epitope, wherein the peptide mimic is constructed to conformationally mimic the conformation of the peptide in the native protein, the peptide mimic contains no charged groups or other immunodominant group, and the peptide mimic is connected to a spacer sequence equivalent to a peptide spacer of between one and thirty amino acids in length, which serves to position the peptide epitope in a conformation that approximates its conformation in the native protein. In a further embodiment the peptide mimic and spacer are linked to a carrier molecule.
REFERENCES:
patent: 4647654 (1987-03-01), Knowles et al.
patent: 4727036 (1988-02-01), Knowles et al.
patent: 5045480 (1991-09-01), Johnson et al.
patent: 5164504 (1992-11-01), Walling et al.
patent: 5484735 (1996-01-01), Davis et al.
patent: 5646255 (1997-07-01), Klein et al.
patent: 5817529 (1998-10-01), Wu
patent: 5876727 (1999-03-01), Swain et al.
patent: 5929237 (1999-07-01), Kahn
patent: 5955582 (1999-09-01), Newman et al.
patent: 0 185 870 (1986-07-01), None
patent: 0 329 994 (1989-08-01), None
patent: 0 598 329 (1994-05-01), None
patent: WO 92/12975 (1992-08-01), None
Bjercke, et al , “Stereospecific monoclonal antibodies to nicotine and cotinine and their use in enzyme-linked immunosorbent assays,”J. Immunol. Meth.90: 203-213 (1986).
Golub, The Cellular basis of the immune response, pp. 256-260, Sinnauer Associates, Inc.: Massachusetts. 1977.
Harlow & Lane,Antibodies-A Laboratory Manual,Cold Spring Harbor: 1988.
Harmon, et al, “The reaction of arylsulfonyl azides with N-methylindole,”J. Org. Chem.38: 11-16 (1973).
Javid, et al., “Immunologic characterization and quantification of haemoglobin A1c,”Brit. J. Haematology38:329-337 (1978).
Karl, et al., “Development and standardization of a new immunoturbidimetric HbA1c,”Klin. Lab39: 991-996 (1993).
Kennett, et al., eds.,Monoclonal Antibodies,Plenum Press: 1980.
Nezlin,Structure and biosynthesis of antibodies,pp. 179-186, Consultants Bureau: New York, 1977.
Parker,Radioimmunoassay of biologically active compounds,pp. 32-35, Prentice-Hall, Inc.: Englewood Cliffs, NJ. 1976.
Prayfair, “The antibody response,” in Immunology at a Glance, Blackwell Scientific Publications: London, 1979.
Roitt,Essential Immunology,Blackwell Scientific Publications: London, 1971.
Deyl and Miksik, “Post-translational non-enzymatic modification of proteins. I. Chromatography of marker adducts with special emphasis to glycation reactions”,J. Chromatogr. B Biomed. Sci. Appt., 699(1-2):287-309 (1997).
Frantzen, “Chromatographic and electrophoretic methods for modified hemoglobins”,J. Chromatogr. B Biomed. Sci. Appl., 699(1-2):269-86(1997).
Furth, “Glycated proteins in diabetes”,Br. J. Biomed. Sci., 54(3):192-200 (1997).
Horiuchi, et al., “Scavenger receptors for oxidized and glycated proteins”,Amino Acids, 25(3-4):283-92 (2003).
Miksik and Deyl, “Post-translational non-enzymatic modification of proteins. II. Separation of selected protein species after glycation and other carbonyl-mediated modifications”,J. Chromatogr. B Biomed.Sci. Appl., 699(1-2):311-45 (1997).
Wautier and Schmidt, “Protein glycation: a firm link to endothelial cell dysfunction”,Circ. Res., 95(3):233-8 (2004).
Fitzpatrick Judith
Lenda Regina
Pabst Patent Group LLP
Serex, Inc.
Shibuya Mark
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