Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2005-11-15
2005-11-15
Woitach, Joseph T. (Department: 1632)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C800S008000, C800S021000, C800S022000, C536S023100
Reexamination Certificate
active
06965022
ABSTRACT:
The present invention provides non-invasive methods and compositions to differentiate, with a high level of sensitivity and specificity, swine that are genetically susceptible to diseases associated with F18E. coliinfection, from resistant swine. DNA polymorphisms in the swine alpha (1,2) fucosyltransferase 1 (FUT1) gene were used to differentiate resistant from susceptible swine. The invention includes a polypeptide with amino acid substitutions, encoded by the nucleotide polymorphisms, a molecular diagnostic assay, and a kit for the differentiation, ofE. coliF18-adhesion resistant, heterozygous (carrier) and homozygous susceptible pigs. The molecular test identifies susceptibility to oedema disease and postweaning diarrhea with high sensitivity and specificity, therefore, is useful to swine breeder in their effort to enhance for resistance. Information on the polymorphisms of the present invention provides insight into causation and treatment ofE. coliassociated intestinal disorders.
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Bosworth Brad T.
Vögeli Peter
Barnes & Thornburg
Martin Alice O.
Swiss Federal Institute of Technology
The United States of America as represented by the Secretary of
Woitach Joseph T.
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