Methods to express genes from viral vectors

Details Methods to express genes from viral vectors Methods to express genes from viral vectors

1999-02-16

2000-09-05

Schwartzman, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 9131, 4353201, 435457, 514 44, 536 245, C12N 1563, C12N 1567, C12N 1586

Patent

active

061141410

ABSTRACT:
The present invention provides a conditionally replicating viral vector, methods of making, modifying, propagating and selectively packaging, and using such a vector, isolated molecules of specified nucleotide and amino acid sequences relevant to such vectors, a pharmaceutical composition and a host cell comprising such a vector, the use of such a host cell to screen drugs. The methods include the prophylactic and therapeutic treatment of viral infection, in particular HIV infection, and, thus, are also directed to viral vaccines and the treatment of cancer, in particular cancer of viral etiology. Other methods include the use of such conditionally replicating viral vectors in gene therapy and other applications.

REFERENCES:
patent: 5144019 (1992-09-01), Rossi et al.
patent: 5180818 (1993-01-01), Cech et al.
patent: 5225337 (1993-07-01), Robertson et al.
patent: 5272262 (1993-12-01), Rossi et al.
patent: 5888767 (1999-03-01), Dropulic et al.
Adachi et al., J. Virol., 59, 284-291 (1986).
Altman, Proc. Natl. Acad. Sci., 90, 10898-10900 (1993).
Anderson, Science, 256, 808-813 (1992).
Baltimore, Nature, 325, 395-396 (1988).
Barr et al., Methods: A Companion to Methods in Enzymology, 4, 169-176.
Benson, et al., J. Exp. Med., 177, 1561-1566 (1993).
Buchschacher, Jr., et al., J. Virol., 66, 2731-2739 (1992).
Buchschacher, Jr. et al., Human Gene Ther., 3, 391-397 (1992).
Buchschacher, Jr., JAMA, 269, 2880-2886 (1993).
Carroll et al., J. Virol., 68, 6047-6051 (1994).
Cech, Science, 236, 1532-1539 (1987).
Chen et al., Nuc. Acids Res., 20, 4581-4589 (1992).
Chen et al., Annals New York Academy of Sciences, 660, 271-273 (1992).
Coffin, Curr. Top. Microbiol. Immunol., 176, 143-164 (1992).
Coffin, Science, 267, 483-489 (1995).
Cohen, Science, 268, 1566 (1995).
Coombs et al., New Engl. J. Med., 321, 1626-1631 (1989).
Cournoyer et al., Ann. Rev. Immunol., 11, 297-329 (1993).
Dropulic et al., J. Virol., 66, 1432-1441 (1992).
Dropulic et al., Methods: A Companion to Methods in Enzymology, 5, 43-49 (1993).
Dropulic et al., Antisense Research and Development, 3, 87-94 (1993).
Dropulic et al., Human Gene Ther., 5, 927-939 (1994).
Dropulic et al., Gene Therapy and Molecular Medicine, Abst. No. C6-310, 391 (Mar. 26-Apr. 1, 1995).
Freed et al., Proc. Natl. Acad. Sci., 89, 70-74 (1992).
Friedmann, Science, 244, 1275-1281 (1989).
Gilboa et al., TIG, 10, 139-144 (1994).
Hampel et al., Nuc. Acids Res., 18, 299-304 (1990).
Harada et al., Science, 563-566 (1985).
Haseloff et al., Nature, 334, 585-591 (1988).
Haseloff et al., Gene, 82, 43-52 (1989).
Ho et al., New Engl. J. Med., 321, 1621-1625 (1989).
Ho et al., Nature, 373, 123-126 (1995).
Inoue et al., Proc. Natl. Acad. Sci., 88, 2278-2282 (1991).
James et al., Annals New York Academy of Sciences, 660, 274-275 (1992).
Kim et al., AIDS Res. & Hum. Restrovir., 9, 875-882 (1993).
Liska et al., J. Gen. Virol., 75, 2955-2962 (1994).
Lusso et al., J. Virol., 69, 3712-3720 (1995).
Malim et al., J. Exp. Med., 176, 1197-1201 (1992).
Marasco et al., Proc. Natl. Acad. Sci., 90, 7889-7893 (1993).
Matthews, AIDS Res. & Hum. Retrovir., 10, 631-632 (1994).
Miller, Nature, 357, 455-460 (1992).
Mulligan, Science, 260, 926-931 (1993).
Myers et al., HIV Sequence Database, Los Alamos Natl. Lab., 1-A-9 to 1-A-17 (Sep. 1992).
Ojwang et al., Proc. Natl. Acad. Sci., 89, 10802-06 (1992).
Page et al., J. Virol., 64, 5270-5276 (1990).
Parolin et al., J. Virol., 68, 3888-3895 (1994).
Pathak et al., Proc. Natl. Acad. Sci., 87, 6024-6028 (1990).
Pearson et al., Proc. Natl. Acad. Sci., 87, 5079-5083 (1990).
Piatak et al., Science, 259, 1749-1754 (1993).
Poznansky et al., J. Virol., 65, 532-536 (1991).
Preston et al., Science, 242, 1168-1171 (1988).
Richardson et al., J. Virol., 67, 3997-4005 (1993).
Richardson et al., J. Gen. Virol., 76, 691-696 (1995).
Roberts et al., Science, 242, 1171-1173 (1988).
Saag et al., Nature, 334, 440-444 (1988).
Saksela et al., Proc. Natl. Acad. Sci., 91, 1104-1108 (1994).
Sarver et al., Science, 247, 1222-1225 (1990).
Sarver et al., J. NTH Res., 5, 63-67 (1993).
Sarver et al., AIDS Res. And Hum. Retrovir., 9, 483-487 (1993).
Stevenson et al., Cell, 53, 483-496 (1988).
Sullenger et al., Cell, 63, 601-608 (1990).
Sullenger et al., Science, 262, 1566-1569 (1994).
Sun et al., Natl. Acad. Sci., 91, 9715-9719 (1994).
Symons, Ann. Rev. Biochem., 61, 641-671 (1992).
Technology Access Report, "Ribozymes for Treating Hepatitis C", 17 (Feb. 1996).
Thierry et al., Proc. Natl. Acad. Sci., 92, 9742-9746 (1995).
Travers et al., Science, 268, 1612-1615 (1995).
Uhlenbeck, Nature, 328, 596-600 (1987).
Weerasinge et al., J. Virol., 65, 5531-5534 (1991).
Wei et al., Nature, 373, 117-122 (1995).
Winslow et al., Virol., 196, 849-854 (1993).
Wu et al., Cancer Res., 52, 3029-3034 (1992).
Yu et al., Proc. Natl. Acad. Sci., 90, 6340-6344 (1993).
Yu et al., Proc. Natl. Acad. Sci., 92, 699-703 (1995).
Yunoki et al., Arch. Virol., 116, 143-158 (1991).
Zaia et al., Annals New York Academy of Sciences, 660, 95-106 (1992).
Zhou et al., Gene, 149, 33-39 (1994).

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