Methods to determine predisposition to hypertension and associat

Details Methods to determine predisposition to hypertension and associat Methods to determine predisposition to hypertension and associat

1992-09-30

1994-12-20

Parr, Margaret

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 235, 935 78, 436 94, C12Q 170, C07H 2104

Patent

active

053745256

ABSTRACT:
The association of molecular variants of the angiotensinogen gene with human hypertension is disclosed. The determination of this association enables the screening of persons to identify those who have a predisposition to high blood presure.

REFERENCES:
Jeunemaitre et al. Cell 71: 169-180 (1992).
Gaillard et al. DNA 8: 87-99 (1989).
Kotelevisev, Y. V. et al. (1981). "Dinucleotide Repeat Polymorphism in the Human Angiotensinogen Gene," Nucl. Acids Res. 19:6978.
Jeunemaitre, X. et al. (1992). "Absence of Linkage Between the Angiotension Converting Enzyme Locus and Human Essential Hypertension," Nature Genetics 1:72-75.
Jeunemaitre, X. et al. (1992). "Sib Pair Linkage Analysis of Renin Gene Haplotypes in Human Essential Hypertension," Human Genetics 88:301-306.

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