Methods to aid in the diagnosis of multiple sclerosis

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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436518, 436524, 436811, G02N 3353, G01N 33543, G01N 33551, C12Q 100

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active

054728487

ABSTRACT:
Disclosed are methods and kits useful in the differential diagnosis of multiple sclerosis. The method involves the use of an immunochemical reagent containing one or more prosomal antigens. Such a method typically involves: obtaining serum from a patient suspected of suffering from multiple sclerosis; contacting the immunochemical agent with the serum; and detecting the presence of immune complexes formed between the prosomal antigen and any antibodies reactive therewith present in the serum.

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Arribas et al, "Autoantibodies against the Multicatalytic Protinase in Patients with Systemic Lupus Erythematosus", J. Exp. Med., 173: 423-427 (Feb. 1991).
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Research Reagent News, vol. 1, Jan. 1, 1990, "Anti-prosomal Mouse monoclonal antibodies," pp. 1-4, published by Organon Teknika, N.V.

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