Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1994-03-07
2000-03-14
Eyler, Yvonne
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 71, 436 63, 436 64, G01N 33574, G01N 3353, G01N 3348
Patent
active
06037134&
ABSTRACT:
The present invention relates to compositions and methods for the prevention, prognostic evaluation, and treatment of oncogenic disorders, especially breast cancer, wherein a protein tyrosine kinase capable of complexing with a member of the SH2- and/or SH3-containing family of adaptor proteins is involved. In a preferred embodiment of the invention, the protein tyrosine kinase is the receptor protein tyrosine kinase HER2, and the adaptor protein is GRB, so that the protein tyrosine kinase/adaptor protein complex is a HER2/GRB-7 complex.
REFERENCES:
patent: 5196446 (1993-03-01), Levitzki et al.
patent: 5217999 (1993-06-01), Levitzki et al.
Osherov, et al. 1993, Selective Inhibition of the Epidermal Growth Factor and HER2/Neu Receptors by Tryphostins, J. Biol. Chem. 268:11134-42.
Ren et al., 1993, Identification of a Ten-Amino Acid Proline-rich SH3 Binding Site, Science 259:1157-61.
Pawson, T. and Schlessinger, J., 1993, SH2 and SH3 Domains, Current Biol.3(7):434-442.
Mayer and Baltimore, 1993, Trends in Cell. Biol. 3:8-13.
Musacchio et al., 1993, The PH Domain: A Common Piece in the Structural Patchwork of Signalling Proteins, Trends in Biochem. Sci. 18:343-8.
Plowman et al., 1993, Heregulin Induces Tyrosine Phosphorylation of HER4/p180.sup.erbB4, Nature 366:473-5.
Peles et al., 1993, Cell Type Specific Interaction of Neu Differentiation Factor (HDF/heregulin) with Neu/HER-2 Suggests Complex Ligand-Receptor Relationships, EMBO J. 12:961-71.
Mayer et al., 1993, A Putative Modular Domain Present In Diverse Signalling Proteins, Cell 73:629-30.
Plowman et al., 1993, Lignad-Specific Activation of HER4/p180.sup.erbB4, a Fourth Member of the Epidermal Growth Factor Receptor Family, PNAS 90:1746-50.
Bowcock et al., 1993, THRA1 and D17S183 Flank an Integral of <4 cM for the Breast-Ovarian Cancer Gene (BRCA1) on Chromosome 17q21, Am. J. Hum. Genetics 52:718-22.
Buday and Downward, 1993, Mol. Cell. Biol. 13:1903-10.
Egan et al., 1993, Association of Sos Ras Exchange Protein with Grb2 is Implicated in Tyrosine Kinase Signal Transduction and Transformation, Nature 363:450-51.
Haslam et al., 1993, Pleckstrin Domain Homology, Nature 363:309-10.
Li et al., 1993, Guanine-Nucleotide-Releasing Factor hSos1 Binds to Grb2 and Links Receptor Tyrosine Kinases to Ras Signalling, Nature 363:85-8.
Skolnick et al., 1993, The SH2/SH3 Domain-Containing Protein GRB2 Interacts with Tyrosine-Phosphorylated IRS1 and SHc: Implications for Insulin Control of ras Signalling, EMBO J. 12:1929-36.
Marini et al., 1993, The Pituitary Hormones Arginine Vasopressin-Neurophysin II and Oxytocin-Neurophysin I Show Close Linkage with Interleukin-1 on Mouse Chromosome 2, Genomics, 15:200-2.
Smith et al., 1993, Topoisomerase II.alpha. co-amplification with erbB2 in Human Primary Breast Cancer and Breast Cancer Cell Lines: Relationship to m-AMSA and mitoxantrone Sensitivity, Oncogene 8:933-8.
Lippman et al., 1993, The Development of Biological Therapies for Breast Cancer, Science 259:631-2.
Schlessinger and Ullrich, 1992, Growth Factor Signalling by Receptor Tyrosine Kinases, Neuron 9:383-91.
Pawson, T. and Gish, J., 1992, SH2 and SH3 Domains: From Structure to Function, Cell 71:359-62.
Scott, JD and Soderling, TR 1992, Serinie/Threonine Protein Kinases, Current Opionion in Neurology 2:289-95.
Ciocca et al., 1992, Correlation of HER-2
eu Amplification with Expression and with Other Prognostic Factors in 1103 Breast Cancers, JNCI 84:1279-82.
Sulston et al., 1992, The C. elegans Genome Sequencing Project: A Beginning, Nature 356:37-41.
Posada et al., 1992, Molecular Signal Integration, Interplay Between Serine, Threonine, and Tyrosine Phsophorylation, Mol. Biol. Cell. 3:583-592.
Margolis,B., 1992, Proteins with SH2 Domains: Transducers in the Tryosine Kinase Signalling Pathway, Cell. Growth. Differ. 3:73-80.
Ron and Dressler, 1992, pGSTag-A Versitile Bacterial Expression Plasmid for Enzymatic Labelling of Recombinant Proteins, Blotechniques, 13:866-9.
Rozakis-Adcock et al., 1992, Association of the Shc and Grb2/Sem5 SH2-Containing Proteins Is Implicated in Activation of the Ras Pathway by Tyrosine Kinases, Nature 360:689-92.
Fischer et al., 1991, Protein Tyrosine Phosphatases: A Diverse Family of Intracellular and Transmembrane Enzymes, Science 253:401-6.
Bellacosa et al., 1991, A Retroviral Oncogene, akt Encoding a Serine-Threonine Kinase Containing an SH2-Like Region, Science 254:274-7.
Pendergast et al., 1991, BCR Sequences Essential for Transformation by the BCR-ABL Oncogene Bind to the ABL SH2 Regulatory Domain in a Non-Phosphotyrosine-Dependent Manner, Cell 66:161-71.
Cantley, et al., 1991, Oncogenes and Signal Transduction, Cell 64:281-302.
Hunter, T., 1991, Cooperation Between Oncogenes, Cell 64:249-70.
Jones et al., 1991, Molecular Cloning and Identification of a Serine/Threonine Protein Kinases of the Second-Messanger Subfamily, PNAS, 88:4171-75.
Hardie, D., 1990, Roles of Protein Kinases and Phosphates in Signal Transduction, Symp. Soc. Exp. Biol. 44:241-255.
Wilks,AF, 1990, Structure and Function of the Protein Tyrosine Kinases, Progress in Growth Fact. Res. 2:97-111.
Kury et al., 1990, Determination of HER-2
eu Amplification and Expression in Tumor Tissue and Cultured Cells Using a Simple, Phenol Free Method for Nucleic Acid Isolation, Oncogene 5:1403-8.
Nurse, P., 1990, Universal Control Mechanism Regulating Onset of M-phase, Nature 344:503-8.
Margolis et al., 1990, Effect of Phospholipase C-.gamma. Overexpression on PDGF-Induced Second Messangers and Mitogenesis, Science 248:607-10.
Sap et al., 1990, Cloning and Expression of a Widely Expressed Receptor Tyrosine Phosphatase, PNAS, 87:6112-6.
Lyall et al., 1989, Tyrophostins Inhibit Epidermal Growth Factor (EGF)-Receptor Tyrosine Kinase Activity in Living Cells and EGF-Stimulated Cell Proliferation, J. Biol. Chem, 264:14503-9.
Buchberg et al., 1989, A Comprehensive Genetic Map of Murine Chromosme 11 Reveals Extensive Linkage Conservation Between Mouse and Human, Genetics 122:153-61.
Lee et al., 1989, HER2 Cytoplasmic Domain Generates Normal Mitogenic and Transforming Signals in a Chimeric Receptor, EMBO J. 8:167-173.
Tavassoli et al., 1989, c-erbB-2/c-erbA Co-amplification Indicative of Lymph Node Metastasis, and c-myc Amplification of High Tumor Grade, in Human Breast Carcinoma, British J. of Cancer 60:505-10.
Slamon et al., 1989, Studies of the HER-2
eu Proto-Oncogene in Human Breast and Ovarian Cancer, Science 244:707-12.
Margolis et al., 1989, EGF Induces Tyrosien Phosphorylation of Phospholipase C-II: A Potential Mechanism for EGF Receptor Signalling, Cell, 57:1101-7.
Gazit et al., 1989, Tyrphostins I: Synthasis and Biological Activity of Protein Tyrosine Kinase Inhibitors, J. Medicinal Chem. 32:2344-52.
Tandon et al., 1989, HER-2
eu Oncogene Protein and Prognosis in Breast Cancer, J. Clin. Oncol. 7:1120-8.
Trahey et al., 1988, Molecular Cloning of Two Types of GAP Complementary DNA from Human Placenta, Science, 242:1697-700.
Stahl et al., 1988, Sequence Similarity of Phospholipase C with the non-catalytic region of src, Nature 332:269-72.
King et al., 1988, EGF Binding to its Receptor Triggers a Rapid Tyrosine Phosphorylation of the erbB-2 Protein in the Mammary Tumor Cell Line SK-BR-3, EMBO J. 7:1647-51.
Mayer et al., 1988, A Novel Viral Oncogene with Structural Similarity to Phospholipase C, Nature 332:272-5.
Tyers et al., 1988, Molecular Cloning and Expression of the Major Protein Kinase C Substrate of Platelets, Nature 333:470-3.
Hanks et al., 1988, The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains, Science 241:42-52.
Vogel et al., 1988, Activation of a Phosphotyrosine Phosphatase by Tyrosine Phosphorylation, Science 259:1611-4.
Slamon et al., 1987, Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2
eu Oncogene, Science 235:177-82.
Van de Vijer et al., 1987, Amplification of the neu (c-erbB-2) Oncogene in Human Mammary Tumors Is Relatively Frequent and Is Often Accompanied by Amplification of the Linked c-erbA Oncogene, Mol. Cel. Biol. 7:2019-23.
Yamamoto et al., 19
Eyler Yvonne
New York University Medical Center
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