Surgery – Diagnostic testing
Patent
1998-02-23
2000-05-23
Nasser, Robert L.
Surgery
Diagnostic testing
128920, 128898, A61N 500
Patent
active
060660910
ABSTRACT:
A first aspect of the invention is a method of estimating a withdrawal interval for an adjusted dose of a compound from a prior withdrawal time for a corresponding prior dose of that compound, corresponding half-life data and a tolerance concentration, for a tissue of interest. The method comprises selecting an adjusted dose for the compound for which a withdrawal interval is to be determined, and extrapolating a withdrawal interval from (a) the prior dose, (b) the prior withdrawal time, (c) the half-life data, and (d) the tolerance concentration. The process is useful for determining a withdrawal interval for an extralabel (i.e., non-approved) use of a drug in the same or a different jurisdiction for which a previous use has been approved, and can be used to determine an appropriate withdrawl interval for a drug in food products exported from one jurisdiction to another. Data processing systems and computer program products for carrying out the foregoing are also disclosed.
REFERENCES:
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Baynes Ronald E.
Craigmill Arthur L.
Martin-Jimenez Tomas
Riviere Jim E.
Astorino Michael
Nasser Robert L.
North Carolina State University
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