Image analysis – Image enhancement or restoration
Reexamination Certificate
2004-09-30
2009-02-10
Wu, Jingge (Department: 2624)
Image analysis
Image enhancement or restoration
C382S255000, C382S279000, C356S124000
Reexamination Certificate
active
07489828
ABSTRACT:
The present invention provides methods, a system, and a program product for the rapid detection and correction of spherical aberration in microscopy systems. More specifically, the present invention empirically derives a pupil function, adaptively corrects PSF parameters, and automatically detects the coefficient for spherical aberration. A first aspect of the invention provides a method for detecting and estimating spherical aberration in an acquired image obtained using an optical system, comprising the steps of deconvolving an image using each of a plurality of point spread functions, wherein each point spread function has a different spherical aberration value, calculating an image energy for each deconvolved image, and choosing as a spherical aberration coefficient the spherical aberration value corresponding to the deconvolved image having the lowest image energy, wherein a spherical aberration coefficient other than 0 indicates the presence of spherical aberration in the acquired image and its distance from 0 is an estimation of the degree and direction of spherical aberration.
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Asad Abu-Tarif
Holmes Timothy J.
Caesar Rivise Bernstein Cohen & Pokotilow Ltd.
Media Cybernetics Inc.
Torres José M
Wu Jingge
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