Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for...
Reexamination Certificate
2006-04-18
2006-04-18
Kerr, Kathleen (Department: 1652)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
C435S320100, C435S252300, C435S254110, C435S419000, C435S325000, C536S023100, C536S023200
Reexamination Certificate
active
07029887
ABSTRACT:
The present invention relates to polynucleotide molecules comprising sequences encoding avec gene products, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures ofStreptomyces avermitilis. AveC genes, homologs and partial homologs thereof are described forS. avermitilis, S. hygroscopicus, andS. griseochromogenes, respectively. The present invention further relates to vectors, host cells, and mutant strains ofStreptomyces avermitilisin which the avec gene has been inactivated, or mutated so as to change the ratio or amount of class 2:1 avermectins produced.
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Katoh Yoshihiro
McArthur Hamish
Stutzman-Engwall Kim J.
Kerr Kathleen
Munchhof Martha G.
Pfizer Inc.
Wootton Thomas A.
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