Methods of using substituted tetralins and indanes

Details Methods of using substituted tetralins and indanes Methods of using substituted tetralins and indanes

2008-04-01

2008-04-01

Eyler, Yvonne (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C514S562000, C514S563000, C562S428000

Reexamination Certificate

active

07351857

ABSTRACT:
The invention features tetralin and indane compounds, compositions containing them, and methods of using them as PPAR alpha modulators to treat or inhibit the progression of, for example, diabetes.

REFERENCES:
patent: 6028109 (2000-02-01), Willson
patent: 6300339 (2001-10-01), Jeppesen et al.
patent: 6306854 (2001-10-01), Brown et al.
patent: 6750236 (2004-06-01), Urbahns et al.
patent: 2005/0240049 (2005-10-01), Zhang-Plasket et al.
patent: 2006/0094786 (2006-05-01), Chen et al.
patent: 2006/0247314 (2006-11-01), Chen et al.
patent: 399422 (1990-11-01), None
patent: 0933422 (1999-04-01), None
patent: WO 92/10468 (1992-06-01), None
patent: WO 95/04713 (1995-02-01), None
patent: WO 97/36579 (1997-10-01), None
patent: WO 00/23407 (2000-04-01), None
patent: WO 00/71506 (2000-11-01), None
patent: WO 02/28821 (2002-04-01), None
patent: WO 02/064130 (2002-08-01), None
patent: WO 02/064146 (2002-08-01), None
patent: WO 02/064549 (2002-08-01), None
PCT International Search Report dated Mar. 25, 2004 for PCT Application No. PCT/EP03/033371 which relates to U.S. Appl. No. 11/145,119.
Assismacopoulos-Jeannet, F. et al. “Effect of a peroxisome proliferator on β-oxidation and overall energy balance in obese (fa/fa) rats”.America Phy. Soc., 1991, pp. R278-R283.
Kliewer, S. A. et al., “Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome prolideratior-activated receptors α and γ.”Proc. Natl. Acad. Sci., 1997, vol. 94, pp. 4318-4323.
Cecchi, R. et al., “Synthesis and β-adrenergic activity of atypical phenylethanolaminotetralin stereoisomers.”Eur. J. Med. Chem. 1994, vol. 29, pp. 259-267.
Brown, P. J. et al., “Identification of peroxisome proliferators-activated receptor ligands from a biased chemical library”,Chem. & Bio., 1997, vol. 4, No. 12, pp. 909-918.
Brown, P. J. et al., “Generation of Secondary Alkyl Amines on Solid Support by Borane Reduction: Application to the Parallel Synthesis of PPAR Lignads”,Synthesis, 1997, pp. 778-782.
Hawke, R. L., et al., “Potent pypocholesterolemic activity of novel ureido phenoxyisobutyrates correlates with their Intrinsic fibrate potency and not with their ACAT inhibitory activity.”J. Lipid Res., 1997, vol. 38, pp. 1189-1203.
Brown, P. J. et al., “Identification of peroxisome proliferator-activated receptor ligands from a biased chemical library.”Chem. & Bio., 1997, vol. 4, No. 12, pp. 909-918.
Brown, P. J., “A Ureido-Thiosobutyric Acid (GW9578) Is a Subtype-Selective PPAR α Agonist with Potent Lipid-Lowering Activity.”J. Med. Chem., 1999, vol. 42, pp. 3785-3788.
Guerre-Millo, M. et al., “Peroxisome Proliferator-activated Receptor α Activators Improve Insulin Sensitivity and Reduce Adiposity.”J. Bio. Chem., 2000, vol. 275, No. 22, pp. 16638-42.
Brown, P.J., “Identification of a Subtype Selective Human PPAR α Agonist Through Parallel-Array Synthesis.”Bioorg. Med. Chem. Lett., 2001, vol. 11, pp. 1225-1227.

Affiliated with

Also associated with

Rating

Methods of using substituted tetralins and indanes does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods of using substituted tetralins and indanes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of using substituted tetralins and indanes will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2768039