Methods of using recombinant human protein C

Details Methods of using recombinant human protein C Methods of using recombinant human protein C

1988-07-05

1992-09-29

Stone, Jacqueline

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

435 76, 435 696, 435226, A61K 3724, C12N 964, C12N 1557, C12Q 137

Patent

active

051512688

ABSTRACT:
The present invention comprises novel DNA compounds which encode human protein C activity. A variety of eukaryotic and prokaryotic recombinant DNA expression vectors have been constructed that comprise the novel protein C activity-encoding DNA and drive expression of protein C activity when transformed into an appropriate host cell. The novel expression vectors can be used to produce protein C derivatives, such as non-carboxylated, non-glycosylated, or non-hydroxylated protein C, and to produce protein C precursors, such as nascent or zymogen protein C, and to produce sub-fragments of protein C, such as active or inactive light and heavy chain. The recombinant-produced protein C activity is useful in the treatment and prevention of a variety of vascular disorders.

REFERENCES:
patent: 4775624 (1988-10-01), Bang et al.
Marlar et al., Blood, vol. 59, No. 5 (May) 1982.
Broekmans et al., (1983), The New England Journal of Medicine 309: 340-344.
Seligsohn et al., (1984), The New England Journal of Medicine 310: 559-562.

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