Methods of using nonpolar grape seed extracts to stimulate...

Details Methods of using nonpolar grape seed extracts to stimulate... Methods of using nonpolar grape seed extracts to stimulate...

2011-06-07

2011-06-07

Clark, Amy L (Department: 1655)

Drug, bio-affecting and body treating compositions

Plant material or plant extract of undetermined constitution...

Containing or obtained from vitis

Reexamination Certificate

active

07955628

ABSTRACT:
The present invention relates to methods of increasing tyrosinase synthesis, expression, or activity in a cell comprising administering to the cell at least one non polar grape seed extract, for example, a nonpolar grape seed extract obtained using hexane as an extraction solvent. The nonpolar grape seed extract may be obtained by any extraction process including solvent sequential fractionation and supercritical fluid extraction.

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Sun et al. “Isolation and purification of dimeric and trimeric proanthocyanidins from grape seeds”. J Chrom A, vol. 841 (1999) 115-121.
Yamakoshi, J., et al., Lightening Effect on Ultraviolet-Induced Pigmentation of Guinea Pig Skin by Oral Administration of a Proanthocyanidin-Rich Extract from Grape Seeds; Pigment Cell Res.; 16:629-638, 2003.

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