Drug – bio-affecting and body treating compositions – Lymphokine
Reexamination Certificate
2006-06-27
2006-06-27
Spector, Lorraine (Department: 1647)
Drug, bio-affecting and body treating compositions
Lymphokine
C424S198100, C514S002600, C530S351000
Reexamination Certificate
active
07067118
ABSTRACT:
A screening method for identifying mutant polypeptides having at least one amino acid difference from a wild type protein involved in a receptor-ligand interaction is disclosed. Also disclosed are mutant polypeptides of the hematopoietic growth factor flt3-Ligand (flt3-L) identified using this method, nucleic acids encoding these flt3-L mutant polypeptides, and methods of treatment involving in vitro and in vivo use of the mutant polypeptides and nucleic acids.
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Graddis Thomas J.
McGrew Jeffrey T.
Finnegan Henderson Farabow Garrett & Dunner LLP
Immunex Corporation
Spector Lorraine
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