Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1997-06-11
2000-08-29
Clark, Deborah J.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
424 932, 424 931, 435440, 435455, 514 44, A01N 6300, A01N 4304, C12N 1510, C12N 1564
Patent
active
061104604
ABSTRACT:
Disclosed herein are methods and compositions for identifying morphogen analogs. Preferred methods rest on the use of test cells comprising DNA defining a morphogen-responsive transcription activating element operatively associated with a reporter gene. In certain embodiments, the methods involve an osteogenic protein 1 (OP-1) responsive transcription activating element. Substances that activate the OP-1 responsive transcription activating element are considered herein likely to be useful for reproducing in vivo effects of morphogens such as OP-1.
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Clark Deborah J.
Creative BioMolecules, Inc.
Elrifi Ivor R.
Morency Michel
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