Methods of using low molecular weight heparins treatment of path

Details Methods of using low molecular weight heparins treatment of path Methods of using low molecular weight heparins treatment of path

1995-02-03

1995-12-12

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 54, 514825, 536 21, 536 54, 536 55, A61K 31725

Patent

active

054749875

ABSTRACT:
The present invention relates to methods for the prevention and/or treatment of pathological processes involving the induction of TNF-.alpha. secretion comprising a pharmaceutically acceptable carrier and a low molecular weight heparin (LMWH). In the pharmaceutical compositions of the present invention, the LMWH is present in a low effective dose and is administered at intervals of about 5-8 days. Furthermore, the LMWH is capable of inhibiting in vitro TNF-.alpha. secretion by resting T cells and/or macrophages in response to T cell-specific antigens, mitogens, macrophage activators, disrupted extracellular matrix (dECM), laminin, fibronectin, and the like.

REFERENCES:
patent: 4281108 (1981-07-01), Fussi
patent: 4401662 (1983-08-01), Lormeau et al.
patent: 4788307 (1988-11-01), Lormeau et al.
patent: 4840941 (1989-06-01), Ueno et al.
patent: 4973580 (1990-11-01), Mascellani et al.
patent: 4990502 (1991-02-01), Lormeau et al.
patent: 5039529 (1991-08-01), Bergendal et al.
Ekre, H.-P. et al. Advances in Experimental Medicine and Biology 1992, 313: 329-340.
Berk, B. C. et al., J. Am. Coll. Cardiol. 1991, 17:111B-117B.
Gervasi, G. B. et al., Arzneim.-Forsch./Drug. Res. 1991, 41:410-413.
Beutler, B. and A. Cerami, Ann. Rev. Immunol. 1989, 7:625-655.
Boneu, B. et al., Thrombosis Research 1987 46:845.
Bratt, G. et al. Thrombosis and Haemostasis 1985, 53:208
Castano, L. and Eisenbarth, G. S. Annu. Reb. Immunol 1990 8:647-679.
Cohen, L. R. et al. Arthritis and Rehumatism 1985 28:841-845.
Colman, R. W. et al. American Journal of Pathology 1976 82(1):25-42.
Elias, D. et al. Proc. Natl. Acad Sci., U.S.A. 1990 87:1576-1580.
Goldberg, I. D. et al. Annals of the New York Academy of Sciences 1986 463:289-291.
Gospodarowicz, D. et al. J. Biol. Chem. 1978 253:3736-3743.
Holoshitz, Y. et al. Science 1983 219:56.
Horvath, J. E. et al. Aust. N. Z. J. Med. 1975 5(6):537-539.
Kiricuta, I. et al. Physiology Chemistry and Physics 1978 10:247-253.
Lider, O. et al. Eur. J. Immunol. 1990, 20:493-499.
Lider, O. et al. J. Clin. Invest. 1989 83:752-756.
Lindhardt, R. J. et al. The Journal of Biological Chemistry 1988 263(26):13090-13096.
Matsuyama, T. et al., J. Viol. 1989, 63(6):2504-2509.
Michihiko, S. et al. Lancet 1989, 1(8648):1206-1207.
Naparstek, Y. et al. Nature 1984 310:241-243.
Okamoto, T. et al. Aids Rs. Hum. Retroviruses 1989, 5(2):131-138.
Ono, K. and Linsay, E. S. J. Thorax. Cardiovasc. Surg. 1969 45:225-229.
Pearson, C. M. Arthritis and Rheumatism 1964 7:80.
Pearson, C. M., Proc. Soc. Exp. Biol. Med. 1956 91:95.
Sy, M. S. et al. Cellular Immunology 1983 82:23-32.
Toivonen, M. L. et al., Meth and Find Exptl. Clin. Pharmacol. 1982 4(6):359-363.
Wallach, D. J. Immunology 1984 132:2464-2469.
Westwick, J. et al. Thrombosis Research 1986 42:435-447.
Linhardt et al; J. Biol. Chem. 257(13):7310-7313 (1982).
Bergqvist et al; Thromb. Res. 32:381-391 (1983).
Larsen et al; J. Pharm. Exp. Ther. 231(2):373-378 (1984).
Redini et al; Biochem. Pharmacol. 37(22):4257-4261 (1988).
Wright, Jr. et al; J. Biol. Chem. 264(3):1534-1542 (1989).
Larsen et al; J. Biol. Chem. 264(3):1570-1577 (1989).
Mattsson et al; Ann. N.Y. Acad. Sci. 556:323-332 (1989).
Fareed et al; Ann. N.Y. Acad. Sci. 556:333-353 (1989).
Dillman et al. Mol. Biother. 1992, 4, 117-121.

Affiliated with

Also associated with

Rating

Methods of using low molecular weight heparins treatment of path does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods of using low molecular weight heparins treatment of path, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of using low molecular weight heparins treatment of path will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1359820