Methods of using lavendamycin analogs

Details Methods of using lavendamycin analogs Methods of using lavendamycin analogs

1994-11-28

1997-07-08

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514255, 514256, 514292, 544238, 544333, 544361, 546 86, 546 87, A61K 3144, A61K 31495, C07D47104, C07D40104

Patent

active

056461500

ABSTRACT:
The invention provides lavendamycin analogs having the following formula: ##STR1## wherein X, Y and R.sup.1 through R.sup.9 are defined in the specification, and salts of these analogs. The invention also provides a method of making the lavendamycin analogs. The lavendamycin analogs have antitumor and antimicrobial activity. Also, methods of treating cancer using lavendamycin methyl ester, 7-butyramido-2-methylquinoline-5,8-dione or 7-butyramido-2-formylquinoline-5,8-dione.

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