Methods of using human von Willebrand factor GPIb binding domain

Details Methods of using human von Willebrand factor GPIb binding domain Methods of using human von Willebrand factor GPIb binding domain

1995-06-05

1999-12-28

Marschel, Ardin H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, A61K 3800

Patent

active

060081937

ABSTRACT:
The subject invention provides non-glycosylated, biologically active polypeptides which comprise the vWF (von Willebrand Factor) GP1b binding domain. These polypeptides may be used to inhibit platelet adhesion and aggregation in the treatment of subjects with conditions such as cerebrovascular disorders and cardiovascular disorders. This invention also provides expression plasmids encoding these polypeptides as well as methods of producing by transforming a bacterial cell and recovering such polypeptides. In addition, the subject invention provides methods of treating and preventing cerebrovascular, cardiovascular and other disorders using these polypeptides to inhibit platelet aggregation.

REFERENCES:
patent: 4620948 (1986-11-01), Builder et al.
patent: 4666884 (1987-05-01), Hawiger et al.
patent: 5200510 (1993-04-01), Kumar et al.
patent: 5238919 (1993-08-01), Zimmerman et al.
patent: 5321127 (1994-06-01), Handin
patent: 5340727 (1994-08-01), Ruggeri et al.
patent: 5344783 (1994-09-01), Scarborough et al.
Pietu et al. "Production in Escherichia coli of a Biologically Active Subfragment of von Willebrand Factor Corresponding to the Platelet Clycoprotein Ib, Collagen And Heparin Binding Domains", Biochemical and Biophysical Research Communications, vol. 1, Nov. 15, 1989.
Andrews et al. "Cross-Linking of a Monomeric 39/34-kDa Dispase Fragment of von Willebrand Factor (Leu-480/Val-48--Gly-718) to the N-Terminal Region of the alpha-Chain of Membrane Glycoprotein Ib on Intact Platelets with Bis(sulfosuccinimidyl) Suberate", 1989.
Kitigawa et al. "Involvement of Platelet Membrane Glycoprotein Ib and Glycoprotein IIb/IIIa Complex in Thrombin-Dependent and -Independent Platelet Aggregations Induced by Tumor Cells", Cancer Research, vol. 49, pp. 537-541, Feb. 1, 1989.
Karpatkin et al. "Role of Adhesive Proteins in Platelet Tumor Inateraction In Vitro and Metastasis Formation in Vivo", Journal of Clinical Investigation, vol. 81, No. 4, pp. 1012-1019, 1988.
McBride et al. "Restenosis After Successful Coronary Angioplasty", The New England Journal of Medicine, vol. 318, No. 26, pp. 1734-1737, Jun. 30, 1988.
Bellinger et al. "Prevention of Occlusive Coronary Artery Thrombosis by a Murine Monoclonal Antibody to Porcine von Willebrand Factor", Proceedings of the National Academy of Sciences USA, vol. 84, pp. 8100-8104, Nov. 1988.
Sadler, et al., PNAS USA 82: 6394-6398 (Oct. 1985).
Girma, et al., Blood, 67: 1356-1366, (May 1986).
Houdijk, et al. "Thrombosis and Haemostasis", 56:(3): 391-396 (Sep. 1986).
Mohri, et al., J. Biological Chemistry, 264 (29): 17361-17367, (Oct. 1989).
Sixma, et al., J. Clinical Investigations 74: 736-744, (Sep. 1984).
Pietu, et al., Biochem. Biophys. Res. Comm. 164: 1339-1347 (Nov. 1989).
Fujimura, et al., J. Biol. Chem. 261: 381-385 (Jan. 1986).
Mohri, et al., J. Biol. Chem. 263: 17901-17904 (Dec. 1988).
Sugimoto, et al., Abstract No. 2371 in Supplement to Circulation, 82: p. III-597 (Oct. 1990).
Andrews, et al., Biochemistry, 28: 8326-8336, (1989).
Sadler et al., Abstract No. 3950 in Federation Proceedings, vol. 44. No. 4, p. 1069 (Mar. 1985).
Lynch et al., Cell, vol. 41, pp. 49-56 (May 1985).
Ginsburg et al., Science, vol. 228, pp. 1401-1406 (Jun. 1985).
Verweij et al., Nucleic Acids Research, vol. 13, No. 13, pp. 4699-4717 (Jul. 1985).
Prior et al., Bio/Technology, vol. 10, pp. 66-73 (Jan. 1992).
Fujimura et al., Abstract No. 1222 in Blood, vol. 66, p. 334a (Nov. 1985).
Gralnick et al., Proc. Nalt. Acad. Sci., vol. 89, pp. 7880-7884 (1992).
Wick et al., J. Clin. Invest., vol. 80, pp. 905-910 (1987).
Peterson et al., Blood, vol. 69, pp. 625-628 (1987).
Yammamoto et al., Thrumbosis Res., vol. 39, pp. 751-759 (1985).
Harmon et al., Bio Chemistry, vol. 27, pp. 2151-2157 (1988).
Pareti et al., J. Biol. Chem. 261(32):15310-15315 (1986).
Fujimura et al., J. Biol. Chem. 262(4):1734-1739 (1987).
Grossi et al., FASEB J. 2(8):2385-2395 (1988).
Mohri et al., CA114:182561m (1990).
Mancuso et al., J. Biol. Chem. 264(33:):19514-19527 (1989).
Carruthers et al., Biochemistry 28:8337-8346 (1989).
Fuster et al., Circulation Res. 51:587-593 (1982).

Affiliated with

Also associated with

Rating

Methods of using human von Willebrand factor GPIb binding domain does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods of using human von Willebrand factor GPIb binding domain, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods of using human von Willebrand factor GPIb binding domain will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2382474