Methods of using hesperetin for sebum control and treatment of a

Details Methods of using hesperetin for sebum control and treatment of a Methods of using hesperetin for sebum control and treatment of a

1994-12-21

1996-12-24

Barts, Samuel

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

514 25, 514 27, 514456, A61K 970

Patent

active

055871763

ABSTRACT:
The subject invention relates to methods for sebum control and treatment of acne in mammalian skin and scalp comprising administration of hesperetin, having the structure: ##STR1## or a pharmaceutically-acceptable salt thereof.

REFERENCES:
patent: 5110801 (1992-05-01), LeVeen et al.
Alcaraz M. J., M. L. Ferrandiz, and A. Villar, "Flavonoid Inhibition of Soybean Lipoxygenase", Pharmazie, vol. 41, pp. 299-300 (1986).
Kimmich G. A. and J. Randles, "Phloretin-like Action of Bioflavonoids on Sugar Accumulation Capability of isolated Intestinal Cells", Membrane Biochemistry, vol. 1, Nos. 3 & 4, pp. 221-237 (1978).
Middleton E., Jr., G. Drzewiecki, and J. Tatum, "The Effects of Citrus Flavonoids on Human Basophil and Neutrophil Function", Planta Medica, vol. 53, pp. 325-328 (1987).
Nishino C., N. Enoki, S. Tawata, A. Mori, K. Kobayashi, and M. Fukushima, "Antibacterial Activity of Flavonoids Against Staphylococcus Epidermis, a Skin Bacterium", Agric. Biol, Chem., vol. 51, pp. 139-143 (1987).
Randles J. and G. Kimmich, "Effects of Phloretin and Theophylline on 3-O-methylglucose Transport by Intestinal Epithelial Cells", American Physiological Society, pp. C64-C72 (1978).
Welton A., L. Tobias, C. Fiedler-Nagy, W. Anderson, W. Hope, K. Meyers, and J. Coffey, "Effect of Flavonoids on Arachiodonic Acid Metabolism", Plant Flavonoids in Biology and Medicine: Biochemical Pharmacological, and Structure-Activity Relationships, pp. 231-242 (1986).
Wilkinson D. I. and E. K. Orenberg, "Effects of Nordihydroguaiaretic Acid, Phloretin, and Phloridzin on the Activity of Adenylate Cyclase, Lipoxygenase and Hexose Transport and Growth of Cultured Keratinocytes", Pharmacology and Therapeutics, vol. 26, pp. 660-666 (1987).

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